Methylation is an essential biochemical mechanism that is central to the transmission of life,
and crucially responsible for regulating gametogenesis and continued embryo development …

Infertility affects nearly 50 million couples worldwide, with 40− 50% of cases having a male
factor component. It is well established that nutritional status impacts reproductive …

Purpose MTHFR, one of the major enzymes in the folate cycle, is known to acquire single-
nucleotide polymorphisms that significantly reduce its activity, resulting in an increase in …

Methylation is a crucially important ubiquitous biochemical process, which covalently adds
methyl groups to a variety of molecular targets. It is the key regulatory process that …

Figure 1. Folate intakes are typically poor in many individuals' diets for several reasons.
Natural folates:(1) are susceptible to oxidation,(2) can rapidly lose activity in foods, and (3) …

In recent years, we have faced an increasing incidence of inflammatory bowel disease (IBD),
especially among young people, affecting them during their reproductive years. The paucity …

Background Over 48.5 million couples are reported with infertility worldwide. Health policy
recommends folic acid in women of childbearing age, particularly in preconception and …

Background: Approximately 10%(190 million) of women worldwide are affected by
endometriosis, ectopic deposits of endometrial tissue that create a major source of pain that …

The C677T polymorphism in the MTHFR gene and its role in folate metabolism, impacting
serum folate metabolites like THF and 5‐MTHF, is a critical but underexplored area in …

Folate plays an essential role in the metabolic regulation of amino acids and nucleic acids,
and in onecarbon metabolism. Folate must be obtained from the diet, and supplementation …