The intricate relationship between type 2 diabetes mellitus (T2DM), insulin resistance (IR), and nonalcoholic fatty liver disease (NAFLD)

DM Tanase, EM Gosav, CF Costea… - Journal of diabetes …, 2020 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) remain as one
of the most global problematic metabolic diseases with rapidly increasing prevalence and …

Brown adipose tissue—a translational perspective

AC Carpentier, DP Blondin, F Haman… - Endocrine …, 2023 - academic.oup.com
Brown adipose tissue (BAT) displays the unique capacity to generate heat through
uncoupled oxidative phosphorylation that makes it a very attractive therapeutic target for …

Atypical antipsychotics and metabolic syndrome: from molecular mechanisms to clinical differences

M Carli, S Kolachalam, B Longoni, A Pintaudi… - Pharmaceuticals, 2021 - mdpi.com
Atypical antipsychotics (AAPs) are commonly prescribed medications to treat schizophrenia,
bipolar disorders and other psychotic disorders. However, they might cause metabolic …

Glucagon-like peptide-1 receptor agonists and dual glucose-dependent insulinotropic polypeptide/glucagon-like peptide-1 receptor agonists in the treatment of …

EM Muzurović, Š Volčanšek… - Journal of …, 2022 - journals.sagepub.com
The obesity pandemic is accompanied by increased risk of developing metabolic syndrome
(MetS) and related conditions: non-alcoholic fatty liver disease (NAFLD)/non-alcoholic …

The future of incretins in the treatment of obesity and non-alcoholic fatty liver disease

CR Andreasen, A Andersen, T Vilsbøll - Diabetologia, 2023 - Springer
In the last few decades, glucagon-like peptide-1 receptor (GLP-1R) agonists have changed
current guidelines and improved outcomes for individuals with type 2 diabetes. However, the …

The roles and mechanisms of lncRNAs in liver fibrosis

Z He, D Yang, X Fan, M Zhang, Y Li, X Gu… - International journal of …, 2020 - mdpi.com
Many studies have revealed that circulating long noncoding RNAs (lncRNAs) regulate gene
and protein expression in the process of hepatic fibrosis. Liver fibrosis is a reversible wound …

Nonalcoholic fatty liver disease: current therapies and future perspectives in drug delivery

I Domingues, IA Leclercq, A Beloqui - Journal of Controlled Release, 2023 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) affects approximately 25% of the adult population
worldwide. This pathology can progress into end-stage liver disease with life-threatening …

Incretins (GLP1 r agonists and dual, triple agonists) and the liver

PN Newsome, P Ambery - Journal of Hepatology, 2023 - Elsevier
The principle pathological drivers of metabolic dysfunction associated steatohepatitis
(MASH) are obesity and associated insulin resistance, rendering them key therapeutic …

Гепатопротекторы

СВ Оковитый, ВА Приходько, НН Безбородкина… - 2022 - elibrary.ru
В настоящем издании проанализированы и систематизированы сведения по
клиническому применению лекарственных средств, для которых гепатотропное …

Incretin hormones in obesity and related cardiometabolic disorders: the clinical perspective

J Michałowska, E Miller-Kasprzak, P Bogdański - Nutrients, 2021 - mdpi.com
The prevalence of obesity continues to grow rapidly worldwide, posing many public health
challenges of the 21st century. Obese subjects are at major risk for serious diet-related …