NLRP3 inflammasome is a multiprotein complex involved in host immune response─ which
exerts various biological effects by mediating the maturation and secretion of IL-1β and IL …

During aging and after traumatic injuries, cartilage and bone cells are exposed to various
pathophysiologic mediators, including reactive oxygen species (ROS), damage-associated …

The NOD-like receptor protein 3 (NLRP3) inflammasome is a protein complex that regulates
innate immune responses by activating caspase-1 and the inflammatory cytokines IL-1β and …

The review considers modern data on the mechanisms of activation and redox regulation of
the NLRP3 inflammasome and gasdermins, as well as the role of selenium in these …

Acute lung injury (ALI) is a prevalent and critical condition in clinical practice. Although
certain pharmacological interventions have demonstrated benefits in preclinical studies …

The NLRP3 inflammasome is pivotal in orchestrating the immune response induced by
nanoparticle adjuvants. Understanding the intricate mechanisms underlying the activation of …

Introduction The release of mature interleukin (IL-) 1β from osteoblasts in response to
danger signals is tightly regulated by the nucleotide-binding oligomerization domain leucine …

Neuropathic pain (NP) is usually treated with analgesics and symptomatic therapy with poor
efficacy and numerous side effects, highlighting the urgent need for effective treatment …

A wide variety and large number of bacterial species live in the gut, forming the gut
microbiota. Gut microbiota not only coexist harmoniously with their hosts, but they also …

Patients with ulcerative colitis (UC) have higher rates of depression. However, the
mechanism of depression development remains unclear. The improvements of EPA and …