Endogenous control mechanisms of FAK and PYK2 and their relevance to cancer development

R Naser, A Aldehaiman, E Díaz-Galicia, ST Arold - Cancers, 2018 - mdpi.com
Focal adhesion kinase (FAK) and its close paralogue, proline-rich tyrosine kinase 2 (PYK2),
are key regulators of aggressive spreading and metastasis of cancer cells. While targeted …

MicroRNAs are involved in the development and progression of gastric cancer

X Liu, R Ma, B Yi, AI Riker, Y Xi - Acta Pharmacologica Sinica, 2021 - nature.com
MicroRNAs (miRNAs) are recognized as an essential component of the RNA family, exerting
multiple and intricate biological functions, particularly in the process of tumorigenesis …

miR-151a-3p-rich small extracellular vesicles derived from gastric cancer accelerate liver metastasis via initiating a hepatic stemness-enhancing niche

B Li, Y Xia, J Lv, W Wang, Z Xuan, C Chen, T Jiang… - Oncogene, 2021 - nature.com
Liver metastasis (LM) severely affects gastric cancer (GC) patients' prognosis. Small
extracellular vesicles (sEVs) play key roles in intercellular communication. Specific sEV …

TIMP-2 inhibits metastasis and predicts prognosis of colorectal cancer via regulating MMP-9

W Wang, D Li, L Xiang, M Lv, L Tao, T Ni… - Cell adhesion & …, 2019 - Taylor & Francis
Colorectal cancer has a common cause of morbidity and mortality. Therefore, it is urgent to
detect reliable biomarkers to predict prognosis in CRC. Here, we determined the expression …

miR-3607-3p suppresses non-small cell lung cancer (NSCLC) by targeting TGFBR1 and CCNE2

P Gao, H Wang, J Yu, J Zhang, Z Yang, M Liu… - PLoS …, 2018 - journals.plos.org
Accumulating evidence indicates that miRNAs can be promising diagnostic and/or
prognostic markers for various cancers. In this study, we identified a novel miRNA, miR-3607 …

Mevalonate pathway enzyme HMGCS1 contributes to gastric cancer progression

IH Wang, TT Huang, JL Chen, LW Chu, YH Ping… - Cancers, 2020 - mdpi.com
The 3-hydroxy-3-methylglutaryl-CoA synthase 1 (HMGCS1) is a potential regulatory node in
the mevalonate pathway that is frequently dysregulated in tumors. This study found that …

[HTML][HTML] MicroRNA-216a inhibits the metastasis of gastric cancer cells by targeting JAK2/STAT3-mediated EMT process

Y Tao, S Yang, Y Wu, X Fang, Y Wang, Y Song, T Han - Oncotarget, 2017 - ncbi.nlm.nih.gov
MicroRNAs (miRNAs), a group of small, non-protein coding, endogenous RNAs, play critical
roles in the tumorigenesis and progression of human cancer. miR-216a has recently been …

[HTML][HTML] miR-769-5p suppressed cell proliferation, migration and invasion by targeting TGFBR1 in non-small cell lung carcinoma

Z Yang, J He, P Gao, Y Niu, J Zhang, L Wang, M Liu… - Oncotarget, 2017 - ncbi.nlm.nih.gov
MicroRNAs (miRNAs) are key regulators of multiple cancers, including non-small cell lung
carcinoma (NSCLC). The aim of this study was to determine the expression pattern of miR …

MicroRNAs in oncogenesis and tumor suppression

S Barbato, G Solaini, M Fabbri - International review of cell and molecular …, 2017 - Elsevier
MicroRNAs (MiRNAs) have emerged in the last 15 years as central players in the biology of
cancer. Increasing lines of evidence have supported their regulatory role in the expression …

NOTCH receptors in gastric and other gastrointestinal cancers: oncogenes or tumor suppressors?

T Huang, Y Zhou, ASL Cheng, J Yu, KF To, W Kang - Molecular cancer, 2016 - Springer
Gastric cancer (GC) ranks the most common cancer types and is one of the leading causes
of cancer-related death. Due to delayed diagnosis and high metastatic frequency, 5-year …