Endogenous control mechanisms of FAK and PYK2 and their relevance to cancer development
Focal adhesion kinase (FAK) and its close paralogue, proline-rich tyrosine kinase 2 (PYK2),
are key regulators of aggressive spreading and metastasis of cancer cells. While targeted …
are key regulators of aggressive spreading and metastasis of cancer cells. While targeted …
MicroRNAs are involved in the development and progression of gastric cancer
X Liu, R Ma, B Yi, AI Riker, Y Xi - Acta Pharmacologica Sinica, 2021 - nature.com
MicroRNAs (miRNAs) are recognized as an essential component of the RNA family, exerting
multiple and intricate biological functions, particularly in the process of tumorigenesis …
multiple and intricate biological functions, particularly in the process of tumorigenesis …
miR-151a-3p-rich small extracellular vesicles derived from gastric cancer accelerate liver metastasis via initiating a hepatic stemness-enhancing niche
B Li, Y Xia, J Lv, W Wang, Z Xuan, C Chen, T Jiang… - Oncogene, 2021 - nature.com
Liver metastasis (LM) severely affects gastric cancer (GC) patients' prognosis. Small
extracellular vesicles (sEVs) play key roles in intercellular communication. Specific sEV …
extracellular vesicles (sEVs) play key roles in intercellular communication. Specific sEV …
TIMP-2 inhibits metastasis and predicts prognosis of colorectal cancer via regulating MMP-9
Colorectal cancer has a common cause of morbidity and mortality. Therefore, it is urgent to
detect reliable biomarkers to predict prognosis in CRC. Here, we determined the expression …
detect reliable biomarkers to predict prognosis in CRC. Here, we determined the expression …
miR-3607-3p suppresses non-small cell lung cancer (NSCLC) by targeting TGFBR1 and CCNE2
P Gao, H Wang, J Yu, J Zhang, Z Yang, M Liu… - PLoS …, 2018 - journals.plos.org
Accumulating evidence indicates that miRNAs can be promising diagnostic and/or
prognostic markers for various cancers. In this study, we identified a novel miRNA, miR-3607 …
prognostic markers for various cancers. In this study, we identified a novel miRNA, miR-3607 …
Mevalonate pathway enzyme HMGCS1 contributes to gastric cancer progression
IH Wang, TT Huang, JL Chen, LW Chu, YH Ping… - Cancers, 2020 - mdpi.com
The 3-hydroxy-3-methylglutaryl-CoA synthase 1 (HMGCS1) is a potential regulatory node in
the mevalonate pathway that is frequently dysregulated in tumors. This study found that …
the mevalonate pathway that is frequently dysregulated in tumors. This study found that …
[HTML][HTML] MicroRNA-216a inhibits the metastasis of gastric cancer cells by targeting JAK2/STAT3-mediated EMT process
Y Tao, S Yang, Y Wu, X Fang, Y Wang, Y Song, T Han - Oncotarget, 2017 - ncbi.nlm.nih.gov
MicroRNAs (miRNAs), a group of small, non-protein coding, endogenous RNAs, play critical
roles in the tumorigenesis and progression of human cancer. miR-216a has recently been …
roles in the tumorigenesis and progression of human cancer. miR-216a has recently been …
[HTML][HTML] miR-769-5p suppressed cell proliferation, migration and invasion by targeting TGFBR1 in non-small cell lung carcinoma
Z Yang, J He, P Gao, Y Niu, J Zhang, L Wang, M Liu… - Oncotarget, 2017 - ncbi.nlm.nih.gov
MicroRNAs (miRNAs) are key regulators of multiple cancers, including non-small cell lung
carcinoma (NSCLC). The aim of this study was to determine the expression pattern of miR …
carcinoma (NSCLC). The aim of this study was to determine the expression pattern of miR …
MicroRNAs in oncogenesis and tumor suppression
MicroRNAs (MiRNAs) have emerged in the last 15 years as central players in the biology of
cancer. Increasing lines of evidence have supported their regulatory role in the expression …
cancer. Increasing lines of evidence have supported their regulatory role in the expression …
NOTCH receptors in gastric and other gastrointestinal cancers: oncogenes or tumor suppressors?
Gastric cancer (GC) ranks the most common cancer types and is one of the leading causes
of cancer-related death. Due to delayed diagnosis and high metastatic frequency, 5-year …
of cancer-related death. Due to delayed diagnosis and high metastatic frequency, 5-year …