Controlled cell death, or apoptosis, occurs in response to many different environmental
stimuli. The apoptotic cascade that occurs within the cell in response to these cues leads to …

Proteases are a diverse group of hydrolytic enzymes, ranging from single-domain catalytic
molecules to sophisticated multi-functional macromolecules. Human proteases are divided …

Pyroptosis is an active and ordered form of programmed cell death. The signaling pathways
of pyroptosis are mainly divided into canonical pathways mediated by caspase-1 and …

Respiratory syncytial virus (RSV) is a major cause of respiratory tract infections in infants, but
an effective vaccine has not yet been developed. An ideal vaccine would elicit protective …

The role of caspase proteases in regulated processes such as apoptosis and inflammation
has been studied for more than two decades, and the activation cascades are known in …

This review takes a closer look at the structural components of the molecules involved in the
processes leading to caspase-1 activation. Interleukins 1β and 18 (IL-1β, IL-18) are well …

Caspase-6 is an apoptotic cysteine protease that also governs disease progression in
Huntington's and Alzheimer's diseases. Caspase-6 is of great interest as a target for …

Most proteases are synthesized in the cell as precursor-containing propeptides. These
structural elements can determine the folding of the cognate protein, function as an …

During maturation, procaspase-3 is cleaved at D175, which resides in a linker that connects
the large and small subunits. The intersubunit linker also connects two active site loops that …

Caspases are a family of cysteine-aspartyl proteases that are well recognized for their
essential roles in apoptosis and inflammation. Recently, caspases have also been linked to …