A large proportion of protein–protein interactions (PPIs) occur between a short peptide and a
globular protein domain; the peptides involved in surface interactions play important roles …

Maleimide chemistry stands out in the bioconjugation toolbox by virtue of its synthetic
accessibility, excellent reactivity, and practicability. The second‐generation of clinically …

Peptides are a growing therapeutic class due to their unique spatial characteristics that can
target traditionally “undruggable” protein–protein interactions and surfaces. Despite their …

Protein–protein interactions (PPIs) are implicated in the majority of cellular processes by
enabling and regulating the function of individual proteins. Thus, PPIs represent high-value …

Protein–protein interactions (PPIs) are vital to all biological processes. These interactions
are often dynamic, sometimes transient, typically occur over large topographically shallow …

We have developed a new concept for reversible peptide stapling that involves
macrocyclization between two amino groups and decyclization promoted via dual 1, 4 …

Herein, we report a versatile reaction platform for tracelessly cleavable cysteine-selective
peptide/protein modification. This platform offers highly tunable and predictable conjugation …

While the global market for peptide/protein-based therapeutics is witnessing significant
growth, the development of peptide drugs remains challenging due to their low oral …

A disulfide click strategy is disclosed for stapling to enhance the metabolic stability and
cellular permeability of therapeutic peptides. A 17‐membered library of stapling reagents …

Water is ubiquitous in olefin metathesis, at levels ranging from contaminant to cosolvent. It is
also non-benign. Water-promoted catalyst decomposition competes with metathesis, even …