Until recently, radiation effects have been considered to be mainly due to nuclear DNA
damage and their management by repair mechanisms. However, molecular biology studies …

As deaths from preventable diseases abate, cancer is becoming one of the leading causes
of death in the world. Photodynamic therapy (PDT) is a noninvasive treatment for cancer …

The metabolic properties of cancer cells diverge significantly from those of normal cells.
Energy production in cancer cells is abnormally dependent on aerobic glycolysis. In addition …

Deregulated cellular energetics was one of the cancer hallmarks. Several underlying
mechanisms of deregulated cellular energetics are associated with mitochondrial …

The traditional view is that cancer cells predominately produce ATP by glycolysis, rather
than by oxidation of energy-providing substrates. Mitochondrial uncoupling—the continuing …

Most cancer cells predominantly produce energy by glycolysis rather than oxidative
phosphorylation via the tricarboxylic acid (TCA) cycle, even in the presence of an adequate …

Currently, radiation therapy is one of the standard therapies for cancer treatment. Since the
first applications, the field of radiotherapy has constantly improved, both in imaging …

Tumor cells have an increased demand for nutrients; this demand is met by increased
availability of nutrients through vasculogenesis and by enhanced cellular entry of nutrients …

The mechanisms of compromised mitochondrial function under various pathological
conditions, including hypoxia, remain largely unknown. Recent studies have shown that …

Background Taxol is one of the most effective chemotherapeutic agents for the treatment of
patients with breast cancer. Despite impressive clinical responses initially, the majority of …