Regulation of cation channels in cardiac and smooth muscle cells by intracellular magnesium

K Mubagwa, A Gwanyanya, S Zakharov… - Archives of biochemistry …, 2007 - Elsevier
Magnesium regulates various ion channels in many tissues, including those of the
cardiovascular system. General mechanisms by which intracellular Mg2+ (Mgi2+) regulates …

Distinct properties of CRAC and MIC channels in RBL cells

JA Kozak, HH Kerschbaum, MD Cahalan - The Journal of general …, 2002 - rupress.org
In rat basophilic leukemia (RBL) cells and Jurkat T cells, Ca2+ release–activated Ca2+
(CRAC) channels open in response to passive Ca2+ store depletion. Inwardly rectifying …

Structure-function studies of voltage-gated ion channels

W Stühmer - Annual review of biophysics and biophysical …, 1991 - annualreviews.org
The rapid development of molecular biology techniques during recent years has opened up
novel possibilities for the study of ion channels at a molecular level. The elucidation of …

Extracellular Mg2+ regulates activation of rat eag potassium channel

H Terlau, J Ludwig, R Steffan, O Pongs, W Stühmer… - Pflügers Archiv, 1996 - Springer
The rat homologue of Drosophila ether à gogo cDNA (rat eag) encodes voltage-activated
potassium (K) channels with distinct activation properties. Using the Xenopus expression …

Inward rectifier potassium channels in plants differ from their animal counterparts in response to voltage and channel modulators

R Hedrich, O Moran, F Conti, H Busch, D Becker… - European Biophysics …, 1995 - Springer
We have investigated the electrophysiological basis of potassium inward rectification of the
KAT1 gene product from Arabidopsis thaliana expressed in Xenopus oocytes and of …

Monovalent permeability, rectification, and ionic block of store-operated calcium channels in Jurkat T lymphocytes

HH Kerschbaum, MD Cahalan - The Journal of general physiology, 1998 - rupress.org
We used whole-cell recording to characterize ion permeation, rectification, and block of
monovalent current through calcium release-activated calcium (CRAC) channels in Jurkat T …

[PDF][PDF] Cytoplasmic polyamines as permeant blockers and modulators of the voltage-gated sodium channel

CJ Huang, E Moczydlowski - Biophysical Journal, 2001 - cell.com
We report that voltage-gated Na+ channels (Na V) from rat muscle (μ1) expressed in
HEK293 cells exhibit anomalous rectification of whole-cell outward current under conditions …

Single point mutations of the sodium channel drastically reduce the pore permeability without preventing its gating

M Pusch, M Noda, W Stühmer, S Numa… - European biophysics …, 1991 - Springer
Two mutants of the sodium channel II have been expressed in Xenopus oocytes and have
been investigated using the patch-clamp technique. In mutant E387Q the glutamic acid at …

Microvillar ion channels: cytoskeletal modulation of ion fluxes

K Lange - Journal of Theoretical Biology, 2000 - Elsevier
The recently presented theory of microvillar Ca2+ signaling [Lange, K.(1999) J. Cell. Physiol.
180, 19–35], combined with Manning's theory of “condensed counterions” in linear …

Ca2+ and Na+ permeability of high‐threshold Ca2+ channels and their volt age‐dependent block by Mg2+ ions in chick sensory neurones

E Carbone, HD Lux, V Carabelli… - The Journal of …, 1997 - Wiley Online Library
1 The Mg2+ block of Na+ and Ca2+ currents through high‐voltage activated (HVA; L‐and N‐
type) Ca2+ channels was studied in chick dorsal root ganglion neurones. 2 In low …