Current understanding of the mechanism of benzene-induced leukemia in humans: implications for risk assessment

CM McHale, L Zhang, MT Smith - Carcinogenesis, 2012 - academic.oup.com
Benzene causes acute myeloid leukemia and probably other hematological malignancies.
As benzene also causes hematotoxicity even in workers exposed to levels below the US …

Stem cell and benzene-induced malignancy and hematotoxicity

L Wang, X He, Y Bi, Q Ma - Chemical research in toxicology, 2012 - ACS Publications
The biological effect of benzene on the hematopoietic system has been known for over a
century. The rapid advancement in understanding the biology of hematopoietic stem cells …

Hsp70 overexpression in Drosophila hemocytes attenuates benzene‐induced immune and developmental toxicity via regulating ROS/JNK signaling pathway

LC D'Souza, S Dwivedi, F Raihan… - Environmental …, 2022 - Wiley Online Library
Benzene, a ubiquitous environmental chemical, is known to cause immune dysfunction and
developmental defects. This study aims to investigate the relation between benzene …

[HTML][HTML] Epigenetic effects of benzene in hematologic neoplasms: the altered gene expression

G Spatari, A Allegra, M Carrieri, G Pioggia, S Gangemi - Cancers, 2021 - mdpi.com
Simple Summary Benzene is produced by diverse petroleum transformation processes and
it is widely employed in industry despite its oncogenic effects. In fact, occupational exposure …

ROS-directed activation of Toll/NF-κB in the hematopoietic niche triggers benzene-induced emergency hematopoiesis

LC D'Souza, N Kuriakose, SV Raghu… - Free Radical Biology …, 2022 - Elsevier
Hematopoietic stem cells/progenitor cells (HSC/HPCs) orchestrate the hematopoietic
process, effectively regulated by the hematopoietic niche under normal and stressed …

[HTML][HTML] Toxicity in hematopoietic stem cells from bone marrow and peripheral blood in mice after benzene exposure: Single-cell transcriptome sequencing analysis

R Sun, K Xu, S Ji, Y Pu, L Yu, L Yin, J Zhang… - … and Environmental Safety, 2021 - Elsevier
Benzene is a ubiquitous, occupational, and environmental hematotoxic and leukemogen.
Damage to hematopoietic stem cells (HSCs) induced by benzene and its metabolites is a …

Proposed mode of action of benzene-induced leukemia: Interpreting available data and identifying critical data gaps for risk assessment

MEB Meek, JE Klaunig - Chemico-biological interactions, 2010 - Elsevier
Mode of action is defined as a series of key biological events leading to an observed
toxicological effect (for example, metabolism to a toxic entity, cell death, regenerative repair …

False positives and false negatives in benzene biological monitoring

A Moghadasi, S Yousefinejad, E Soleimani - Environmental Research, 2023 - Elsevier
Benzene is a commonly used industrial chemical that is a significant environmental
pollutant. Occupational health specialists and industrial toxicologists are concerned with …

A novel TXNIP‐based mechanism for Cx43‐mediated regulation of oxidative drug injury

K Gao, Y Chi, X Zhang, H Zhang, G Li… - Journal of Cellular …, 2015 - Wiley Online Library
Gap junctions (GJ s) play an important role in the regulation of cell response to many drugs.
However, little is known about their mechanisms. Using an in vitro model of cytotoxicity …

Phenolic metabolites of benzene inhibited the erythroid differentiation of K562 cells

XR Wu, M Xue, XF Li, Y Wang, J Wang, QL Han, ZC Yi - Toxicology letters, 2011 - Elsevier
Benzene is a common occupational hazard and a ubiquitous environmental pollutant.
Benzene exposure at the levels even below 1 ppm still showed hematotoxicity. It is widely …