Sickle cell syndromes, including sickle cell disease (SCD) and sickle cell trait, are
associated with multiple kidney abnormalities. Young patients with SCD have elevated …

Sickle cell disease (SCD), which affects approximately 100,000 individuals in the USA and
more than 3 million worldwide, is caused by mutations in the βb globin gene that result in …

It is critical to characterize the natural history of albuminuria in patients with sickle cell
anemia (SCA); however, these data are currently lacking and affecting evidence-based …

Whether the underlying mutations are homozygous, heterozygous, or co-inherited with other
hemoglobinopathies, sickle cell disease is known to afflict the kidneys, leading to the clinical …

The kidneys are among the most commonly affected organ systems in patients with sickle
cell anemia (SCA) and an estimated 15% of deaths in patients with SCA are attributed to …

Sickle cell disease (SCD) is characterized by red blood cell sickling, vaso-occlusion,
hemolytic anemia, damage to multiple organ systems, and, as a result, shortened life …

Glomerular hyperfiltration is common in sickle cell disease (SCD) and precedes proteinuria
and declining kidney function. We evaluated hyperfiltration in SCD patients and its …

Sickle cell disease causes several kidney manifestations. They include defects in urine
concentration, impaired handling of potassium and hydrogen ion, albuminuria, acute kidney …

Background The vascular endothelium is markedly disrupted in sickle cell disease (SCD)
and is the converging cascade of the complex pathophysiologic processes linked to sickle …

The long‐term consequences of pre‐eclampsia (PrE) for renal function have never been
determined in patients with sickle cell disease (SCD). Between 2008 and 2015, we …