Although available data are still limited, real-world evidence regarding mainly ceftolozane-
tazobactam and ceftazidime-avibactam could support the administration of novel beta …

Acute kidney injury represents a common complication in critically ill patients affected by
septic shock and in many cases continuous renal replacement therapy (CRRT) may be …

Objectives: To perform a pharmacokinetic/pharmacodynamic (PK/PD) analysis of continuous-
infusion (CI) fosfomycin combined with extended-infusion (EI) cefiderocol or CI ceftazidime …

Antimicrobial resistance is a global health threat. Among Gram-negative bacteria, resistance
to carbapenems, a class of β-lactam antibiotics, is usually a proxy for difficult-to-treat …

Objectives Data on the use of intravenous (IV) fosfomycin in Canada are limited. Using data
captured by the Canadian LEadership on Antimicrobial Real-life usage (CLEAR) registry …

Therapeutic options for infections caused by vancomycin-resistant enterococci are currently
suboptimal. Combination regimens where fosfomycin is used alongside existing treatments …

Background For treatment of ventriculitis, vancomycin and meropenem are frequently used
as empiric treatment but cerebrospinal fluid (CSF) penetration is highly variable and may …

Introduction Hospital-acquired bacterial pneumonia (HABP) and ventilator-associated
bacterial pneumonia (VABP) continue to be common infections causing significant morbidity …

Background Intravenous fosfomycin (IVFOF) is gaining interest in severe infections. Its use
may be limited by adverse events (AEs). Little experience exists on IVFOF therapeutic drug …

Infections caused by KPC-producing K. pneumoniae continue to pose a significant clinical
challenge due to their emerging resistance to new antimicrobials. We investigated the …