Type III secretion in Chlamydia

EA Rucks - Microbiology and Molecular Biology Reviews, 2023 - Am Soc Microbiol
Type III secretion systems (T3SSs) are utilized by Gram-negative pathogens to enhance
their pathogenesis. This secretion system is associated with the delivery of effectors through …

Recent advances in genetic systems in obligate intracellular human-pathogenic bacteria

DJ Fisher, PA Beare - Frontiers in Cellular and Infection Microbiology, 2023 - frontiersin.org
The ability to genetically manipulate a pathogen is fundamental to discovering factors
governing host–pathogen interactions at the molecular level and is critical for devising …

The inclusion membrane protein IncS is critical for initiation of the Chlamydia intracellular developmental cycle

ME Cortina, RC Bishop, BA DeVasure… - PLoS …, 2022 - journals.plos.org
All Chlamydia species are obligate intracellular bacteria that undergo a unique biphasic
developmental cycle strictly in the lumen of a membrane bound compartment, the inclusion …

Molecular pathogenesis of Chlamydia trachomatis

B Jury, C Fleming, WM Huston… - Frontiers in Cellular and …, 2023 - frontiersin.org
Chlamydia trachomatis is a strict intracellular human pathogen. It is the main bacterial cause
of sexually transmitted infections and the etiologic agent of trachoma, which is the leading …

Contributions of diverse models of the female reproductive tract to the study of Chlamydia trachomatis-host interactions

FC Walker, I Derré - Current Opinion in Microbiology, 2024 - Elsevier
Highlights•Chlamydia infections have damaging consequences on female reproductive
health.•Diverse model systems are required to understand Chlamydia-host …

Advances in genetic manipulation of Chlamydia trachomatis

W Wan, D Li, D Li, J Jiao - Frontiers in Immunology, 2023 - frontiersin.org
Chlamydia trachomatis, one species of Chlamydia spp., has the greatest impact on human
health and is the main cause of bacterial sexually transmitted diseases and preventable …

Sigma 54-Regulated transcription is associated with membrane reorganization and type III secretion effectors during conversion to infectious forms of Chlamydia …

KR Soules, SD LaBrie, BH May, PS Hefty - MBio, 2020 - Am Soc Microbiol
Chlamydia bacteria are obligate intracellular organisms with a phylum-defining biphasic
developmental cycle that is intrinsically linked to its ability to cause disease. The progression …

[HTML][HTML] An inducible transposon mutagenesis approach for the intracellular human pathogen Chlamydia trachomatis

CE O'Neill, RJ Skilton, J Forster, DW Cleary… - Wellcome open …, 2021 - ncbi.nlm.nih.gov
Background: Chlamydia trachomatis is a prolific human pathogen that can cause serious
long-term conditions if left untreated. Recent developments in Chlamydia genetics have …

A minimal replicon enables efficacious, species-specific gene deletion in Chlamydia and extension of gene knockout studies to the animal model of infection using …

KA Fields, MD Bodero, KR Scanlon… - Infection and …, 2022 - Am Soc Microbiol
The genus Chlamydia consists of diverse, obligate intracellular bacteria that infect various
animals, including humans. Although chlamydial species share many aspects of the typical …

[PDF][PDF] Host cell death during infection with Chlamydia: a double-edged sword

BS Sixt - FEMS Microbiology Reviews, 2021 - academic.oup.com
The phylum Chlamydiae constitutes a group of obligate intracellular bacteria that infect a
remarkably diverse range of host species. Some representatives are significant pathogens …