Brown adipose tissue (BAT) displays the unique capacity to generate heat through
uncoupled oxidative phosphorylation that makes it a very attractive therapeutic target for …

The prevalence of obesity and associated chronic diseases continues to increase
worldwide, negatively impacting on societies and economies. Whereas the association …

Obesity induces chronic inflammation resulting in insulin resistance and metabolic
disorders. Cold exposure can improve insulin sensitivity in humans and rodents, but the …

The obesity epidemic shows no signs of abatement. Genetics and overnutrition together with
a dramatic decline in physical activity are the alleged main causes for this pandemic. While …

Overweight and obesity have become a world-wide problem. However, effective intervention
approaches are limited. Brown adipose tissue, which helps maintain body temperature and …

Great progress has been made in identifying positive regulators that activate adipocyte
thermogenesis, but negative regulatory signaling of thermogenesis remains poorly …

Brown adipose tissue (BAT) controls mammalian core body temperature by non-shivering
thermogenesis. BAT is extraordinarily rich in mitochondria, which have the peculiarity of …

Mitochondrial proteases are emerging as key regulators of mitochondrial plasticity and
acting as both protein quality surveillance and regulatory enzymes by performing highly …

The incidence of metabolism-related diseases like obesity and type 2 diabetes mellitus has
reached pandemic levels worldwide and increased gradually. Most of them are listed on the …

The ability to generate thermogenic fat could be a targeted therapy to thwart obesity and
improve metabolic health. Brown and beige adipocytes are two types of thermogenic fat …