The promise of viral vector‐based gene therapy (GT) as a transformative paradigm for
treating severely debilitating and life‐threatening diseases is slowly coming to fruition with …

Natural language processing (NLP) is a branch of artificial intelligence, which combines
computational linguistics, machine learning, and deep learning models to process human …

HKS21542, a highly selective activator of peripheral kappa opioid receptor agonists, plays a
critical role in antinociception and itch inhibition during clinical development. Due to its …

Model-informed drug development (MIDD) refers to the integration and quantitative study of
physiological, pharmacological, and disease process information using modeling and …

Model‐based meta‐analysis (MBMA) can be used in assisting drug development and
optimizing treatment in clinical practice, potentially reducing costs and accelerating drug …

The chapter emphasizes the importance of a well-constructed physiologically-based
pharmacokinetic model in drug development to enhance mechanistic understanding of …

Over the last decades, biological macromolecules have attracted growing attention and
have become an important therapeutic modality. Biological macromolecules are peptide …