The advent of ribosome profiling and other tools to probe mRNA translation has revealed
that codon bias—the uneven use of synonymous codons in the transcriptome—serves as a …

MicroRNAs (miRNAs) are small noncoding RNAs that extensively regulate gene expression
in animals, plants, and protozoa. miRNAs function posttranscriptionally by usually base …

Epitranscriptomic RNA modifications constitute a critical gene regulatory component that can
affect cancer progression. Among these, the RNA N4-acetylcytidine (ac4C) modification …

Despite clear evidence that exosomal microRNAs (miRNAs) are able to modulate the
cellular microenvironment and that exosomal RNA cargo selection is deregulated in …

Tumor mutational burden and heterogeneity has been suggested to fuel resistance to many
targeted therapies. The cytosine deaminase APOBEC proteins have been implicated in the …

Fragile X syndrome (FXS), the most-frequently inherited form of intellectual disability and the
most-prevalent single-gene cause of autism, results from a lack of fragile X mental …

The hnRNPs (heterogeneous nuclear ribonucleoproteins) are RNA-binding proteins with
important roles in multiple aspects of nucleic acid metabolism, including the packaging of …

Translation of cellular mRNAs via initiation at Internal Ribosome Entry Sites (IRESs) has
received increased attention during recent years due to its emerging significance for many …

The control of mRNA stability is an important process that allows cells to not only limit, but
also rapidly adjust, the expression of regulatory factors whose over expression may be …

Adoptive transfer of dendritic cells (DCs) transfected with in vitro–transcribed, RNA-
encoding, tumor-associated antigens has recently entered clinical testing as a promising …