The maintenance of iron homeostasis is essential for proper cardiac function. A growing
body of evidence suggests that iron imbalance is the common denominator in many …

Anemia of inflammation (AI), also known as anemia of chronic disease (ACD), is regarded
as the most frequent anemia in hospitalized and chronically ill patients. It is prevalent in …

Background Ferroptosis is a newly defined form of regulated cell death characterized by the
iron-dependent accumulation of lipid peroxidation and is involved in various …

Ferroptosis is a new type of oxidative regulated cell death (RCD) driven by iron-dependent
lipid peroxidation. As major sites of iron utilization and master regulators of oxidative …

Immunometabolism explores how the intracellular metabolic pathways in immune cells can
regulate their function under different micro-environmental and (patho-)-physiological …

The transferrin receptor 1 (TfR1), also known as cluster of differentiation 71 (CD71), is a type
II transmembrane glycoprotein that binds transferrin (Tf) and performs a critical role in …

This is the fifth in the series of reviews developed as part of the Biomarkers of Nutrition for
Development (BOND) program. The BOND Iron Expert Panel (I-EP) reviewed the extant …

Ferroptosis is a new form of regulated cell death. Several studies have demonstrated that
ferroptosis was involved in multiple diseases. However, the precise role of ferroptosis in …

Iron accumulation is a key mediator of several cytotoxic mechanisms leading to the
impairment of redox homeostasis and cellular death. Iron overload is often associated with …

Introduction: Mitochondria are cellular organelles that perform numerous bioenergetic,
biosynthetic, and regulatory functions and play a central role in iron metabolism …