Neurocritical care depends, in part, on careful patient monitoring but as yet there are little
data on what processes are the most important to monitor, how these should be monitored …

Hyperglycemia after severe traumatic brain injury (TBI) occurs frequently and is associated
with poor clinical outcome and increased mortality. In this review, we highlight the …

Microdialysis enables the chemistry of the extracellular interstitial space to be monitored.
Use of this technique in patients with acute brain injury has increased our understanding of …

Secondary insults can adversely influence outcome following severe traumatic brain injury.
Monitoring of cerebral extracellular chemistry with microdialysis has the potential for early …

The role of neuroinflammation is increasingly being recognised in a diverse range of
cerebral pathologies, including traumatic brain injury (TBI). We used cerebral microdialysis …

Objectives: To analyze the effect of tight glycemic control with the use of intensive insulin
therapy on cerebral glucose metabolism in patients with severe brain injury. Design …

Rationale: Fluid resuscitation is widely considered a life-saving intervention in septic shock;
however, recent evidence has brought both its safety and efficacy in sepsis into question …

Many decisions in drug development and medical practice are based on measuring blood
concentrations of endogenous and exogenous molecules. Yet most biochemical and …

Cerebral vasospasm is a potentially incapacitating or lethal complication in patients with
aneurysmal subarachnoid hemorrhage (SAH). The development of effective preventative …

Traumatic brain injury (TBI) is a major cause of morbidity and mortality worldwide. The
modern management of severe TBI has fallen into the domain of a multidisciplinary team led …