The organization of the stress system and its dysregulation in depressive illness
PW Gold - Molecular psychiatry, 2015 - nature.com
Stressors are imminent or perceived challenges to homeostasis. The stress response is an
innate, stereotypic, adaptive response to stressors that has evolved in the service of …
innate, stereotypic, adaptive response to stressors that has evolved in the service of …
The physiology of regulated BDNF release
T Brigadski, V Leßmann - Cell and Tissue Research, 2020 - Springer
The neurotrophic factor BDNF is an important regulator for the development of brain circuits,
for synaptic and neuronal network plasticity, as well as for neuroregeneration and …
for synaptic and neuronal network plasticity, as well as for neuroregeneration and …
Hallmarks of peripheral nerve function in bone regeneration
Skeletal tissue is highly innervated. Although different types of nerves have been recently
identified in the bone, the crosstalk between bone and nerves remains unclear. In this …
identified in the bone, the crosstalk between bone and nerves remains unclear. In this …
Neurobiology of local and intercellular BDNF signaling
M Sasi, B Vignoli, M Canossa, R Blum - Pflügers Archiv-European Journal …, 2017 - Springer
Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family of secreted
proteins. Signaling cascades induced by BDNF and its receptor, the receptor tyrosine kinase …
proteins. Signaling cascades induced by BDNF and its receptor, the receptor tyrosine kinase …
Voluntary exercise boosts striatal dopamine release: evidence for the necessary and sufficient role of BDNF
Physical exercise improves motor performance in individuals with Parkinson9s disease and
elevates mood in those with depression. Although underlying factors have not been …
elevates mood in those with depression. Although underlying factors have not been …
Emerging connections between cerebellar development, behaviour and complex brain disorders
A Sathyanesan, J Zhou, J Scafidi, DH Heck… - Nature Reviews …, 2019 - nature.com
The human cerebellum has a protracted developmental timeline compared with the
neocortex, expanding the window of vulnerability to neurological disorders. As the …
neocortex, expanding the window of vulnerability to neurological disorders. As the …
Brain metabolism in Alzheimer's disease: biological mechanisms of exercise
L Xu, R Liu, Y Qin, T Wang - Translational neurodegeneration, 2023 - Springer
Alzheimer's disease (AD) is a major subtype of neurodegenerative dementia caused by long-
term interactions and accumulation of multiple adverse factors, accompanied by …
term interactions and accumulation of multiple adverse factors, accompanied by …
CREB family transcription factors are major mediators of BDNF transcriptional autoregulation in cortical neurons
BDNF signaling via its transmembrane receptor TrkB has an important role in neuronal
survival, differentiation, and synaptic plasticity. Remarkably, BDNF is capable of modulating …
survival, differentiation, and synaptic plasticity. Remarkably, BDNF is capable of modulating …
TNF-α differentially regulates synaptic plasticity in the hippocampus and spinal cord by microglia-dependent mechanisms after peripheral nerve injury
Clinical studies show that chronic pain is accompanied by memory deficits and reduction in
hippocampal volume. Experimental studies show that spared nerve injury (SNI) of the sciatic …
hippocampal volume. Experimental studies show that spared nerve injury (SNI) of the sciatic …
[HTML][HTML] Relationships of peripheral IGF-1, VEGF and BDNF levels to exercise-related changes in memory, hippocampal perfusion and volumes in older adults
Animal models point towards a key role of brain-derived neurotrophic factor (BDNF), insulin-
like growth factor-I (IGF-I) and vascular endothelial growth factor (VEGF) in mediating …
like growth factor-I (IGF-I) and vascular endothelial growth factor (VEGF) in mediating …