[HTML][HTML] The interplay between androgens and the immune response in polycystic ovary syndrome
S Shabbir, E Khurram, VS Moorthi, YTH Eissa… - Journal of Translational …, 2023 - Springer
Polycystic ovary syndrome (PCOS) is a metabolic-reproductive-endocrine disorder that,
while having a genetic component, is known to have a complex multifactorial etiology. As …
while having a genetic component, is known to have a complex multifactorial etiology. As …
Extra-adrenal glucocorticoid biosynthesis: implications for autoimmune and inflammatory disorders
RM Slominski, RC Tuckey, PR Manna, AM Jetten… - Genes & …, 2020 - nature.com
Glucocorticoid synthesis is a complex, multistep process that starts with cholesterol being
delivered to the inner membrane of mitochondria by StAR and StAR-related proteins. Here …
delivered to the inner membrane of mitochondria by StAR and StAR-related proteins. Here …
The significance of CYP11A1 expression in skin physiology and pathology
RM Slominski, C Raman, C Elmets, AM Jetten… - Molecular and cellular …, 2021 - Elsevier
CYP11A1, a member of the cytochrome P450 family, plays several key roles in the human
body. It catalyzes the first and rate-limiting step in steroidogenesis, converting cholesterol to …
body. It catalyzes the first and rate-limiting step in steroidogenesis, converting cholesterol to …
[HTML][HTML] Vitamin D signaling in psoriasis: pathogenesis and therapy
AA Brożyna, RM Slominski, B Nedoszytko… - International Journal of …, 2022 - mdpi.com
Psoriasis is a systemic, chronic, immune-mediated disease that affects approximately 2–3%
of the world's population. The etiology and pathophysiology of psoriasis are still unknown …
of the world's population. The etiology and pathophysiology of psoriasis are still unknown …
[HTML][HTML] Effects of phthalate mixtures on ovarian folliculogenesis and steroidogenesis
EJ Fletcher, R Santacruz-Márquez, VE Mourikes… - Toxics, 2022 - mdpi.com
The female reproductive system is dependent upon the health of the ovaries. The ovaries
are responsible for regulating reproduction and endocrine function. Throughout a female's …
are responsible for regulating reproduction and endocrine function. Throughout a female's …
[HTML][HTML] Male sex hormones, aging, and inflammation
JM Ketchem, EJ Bowman, CM Isales - Biogerontology, 2023 - Springer
Adequate levels of androgens (eugonadism), and specifically testosterone, are vital
compounds for male quality of life, longevity, and positive health outcomes. Testosterone …
compounds for male quality of life, longevity, and positive health outcomes. Testosterone …
Short‐term rapamycin treatment increases ovarian lifespan in young and middle‐aged female mice
X Dou, Y Sun, J Li, J Zhang, D Hao, W Liu, R Wu… - Aging cell, 2017 - Wiley Online Library
Although age‐related ovarian failure in female mammals cannot be reversed, recent
strategies have focused on improving reproductive capacity with age, and rapamycin is one …
strategies have focused on improving reproductive capacity with age, and rapamycin is one …
[HTML][HTML] FDX1 regulates leydig cell ferroptosis mediates PM2. 5-induced testicular dysfunction of mice
L Li, Z Pei, R Wu, Y Zhang, Y Pang, H Hu, W Hu… - Ecotoxicology and …, 2023 - Elsevier
Epidemiological studies have established an association between chronic exposure to PM
2.5 and male infertility. However, the underlying mechanisms were not fully revealed. In this …
2.5 and male infertility. However, the underlying mechanisms were not fully revealed. In this …
Safflower seed oil improves steroidogenesis and spermatogenesis in rats with type II diabetes mellitus by modulating the genes expression involved in …
Ethnopharmacological relevance Diabetes mellitus (DM), as a multiorgan syndrome, is an
endocrine and metabolic disorder that is associated with male reproductive system …
endocrine and metabolic disorder that is associated with male reproductive system …
Effect of cadmium exposure during and after pregnancy of female
W Ali, Y Bian, H Zhang, IH Qazi, H Zou… - Environmental …, 2023 - Taylor & Francis
Cadmium is a common environmental pollutant and used for industrial purposes all over the
world. Cadmium exposure causes a variety of public health issues, mainly reproductive …
world. Cadmium exposure causes a variety of public health issues, mainly reproductive …