Polycystic kidney disease is typified by cysts in the kidney and extra-renal manifestations
including hypertension and heart failure. The main genetic underpinning this disease are …

Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disorder, which is
caused by mutations in the PKD1 and PKD2 genes, characterizing by progressive growth of …

The aging process leads to progressive loss of kidney function. Sirtuin1 (SIRT1) exerts
renoprotective effects by conferring resistance to cellular stresses. Trehalose potentially …

Autophagy is a highly conserved cellular progress for the degradation of cytoplasmic
contents including micromolecules, misfolded proteins, and damaged organelles that has …

Pre-clinical animal models are needed to investigate and study kidney injuries and
diseases. The rabbit kidney model is frequently used because various important parameters …

Autosomal dominant polycystic kidney disease (ADPKD) is a monogenic disorder
accounting for approximately 5% of patients with renal failure, yet therapeutics for the …

Autosomal dominant polycystic kidney disease (ADPKD) is mainly caused by deficiency of
polycystin-1 (PC1) or polycystin-2 (PC2). Altered autophagy has recently been implicated in …

Mitophagy, the selective removal of damaged mitochondria, plays a critical role in kidney
diseases, but its involvement in hypertensive nephropathy (HTN) is not well understood. To …

Background: The increasing prevalence of atrial fibrillation (AF) and chronic kidney diseases
highlights the need for a deeper comprehension of the molecular mechanisms linking them …

Trehalose, a natural disaccharide, exists widely in various forms in nature. Due to its unique
roles in cell protection and stress tolerance, researches on trehalose and its potential …