Neuronal nicotinic acetylcholine receptors (nAChRs) belong to a super-family of Cysloop
ligand-gated ion channels that respond to endogenous acetylcholine (ACh) or other …

Four major receptor families enable cells to respond to chemical and physical signals from
their proximal environment. The ligand-and voltage-gated ion channels, G-protein-coupled …

Molecular dynamics (MD) and related methods are close to becoming routine computational
tools for drug discovery. Their main advantage is in explicitly treating structural flexibility and …

The nicotinic acetylcholine receptor (nAChR) belongs to a superfamily of pentameric ligand-
gated ion channels involved in many physiologic and pathologic processes. Among …

Positive allosteric modulators (PAMs), negative allosteric modulators (NAMs), silent
agonists, allosteric activating PAMs and neutral or silent allosteric modulators are …

Abstract Bacopa monnieri (L.)–(BM) is a perennial, creeping herb which is widely used in
traditional ayurvedic medicine as a neural tonic to improve intelligence and memory …

The M1 and M4 muscarinic acetylcholine receptors (mAChRs) are highly pursued drug
targets for neurological diseases, in particular for Alzheimer's disease and schizophrenia …

Nicotinic acetylcholine receptors (nAChRs) are pentameric ligand‐gated ion channels
involved in many physiological and pathological processes. In vertebrates, there are …

Considerable progress has been made in recent years towards the identification and
characterisation of novel subtype-selective modulators of nicotinic acetylcholine receptors …

Although 193 states have committed to the Chemical Weapons Convention and 98% of the
declared chemical weapons stockpiles have been destroyed so far, nerve agent poisoning …