Amiodarone: an overview of its pharmacological properties, and review of its therapeutic use in cardiac arrhythmias

J Gill, RC Heel, A Fitton - Drugs, 1992 - Springer
Synopsis Amiodarone, originally developed over 20 years ago, is a potent antiarrhythmic
drug with the actions of all antiarrhythmic drug classes. It has been successfully used in the …

Pharmacology and pharmacokinetics of amiodarone.

MD Freedman, JC Somberg - Journal of clinical pharmacology, 1991 - europepmc.org
Amiodarone is a unique antiarrhythmic agent originally developed as a vasodilator.
Classified electrophysiologically as a Type III antiarrhythmic, it also has both nonspecific …

Relation of clinical and angiographic factors to functional capacity as measured by the Duke Activity Status Index

CL Nelson, JE Herndon, DB Mark, DB Pryor… - The American journal of …, 1991 - Elsevier
Improvement of patient functional status is an important goal in the therapy of cardiovascular
disease. Given the pressures on the medical profession to restrain the growth of health care …

Parenteral magnesium sulfate versus amiodarone in the therapy of atrial tachyarrhythmias: a prospective, randomized study

JL Moran, J Gallagher, SL Peake… - Critical care …, 1995 - journals.lww.com
Parenteral magnesium sulfate versus amiodarone in the therap... : Critical Care Medicine
Parenteral magnesium sulfate versus amiodarone in the therapy of atrial tachyarrhythmias: A …

Potentially significant drug interactions of class III antiarrhythmic drugs

W Yamreudeewong, M DeBisschop, LG Martin… - Drug Safety, 2003 - Springer
Class III antiarrhythmic drugs, especially amiodarone (a broad-spectrum antiarrhythmic
agent), have gained popularity for use in clinical practice in recent years. Other class III …

Management of atrial tachyarrhythmias in the critically ill: a comparison of intravenous procainamide and amiodarone

MJ Chapman, JL Moran, MS O'Fatharaigh… - Intensive care …, 1993 - Springer
Objective To compare the efficacy and safety of intravenous (IV) amiodarone and
procainamide for the treatment of atrial tachyarrhythmias (AT) in the critically ill. Design In …

Side effects with amiodarone therapy

R Shukla, NI Jowett, DR Thompson… - Postgraduate medical …, 1994 - academic.oup.com
Amiodarone hydrochloride is increasingly being used in the treatment of ventricular and
supraventricular arrhythmias. Although a highly effective anti-arrhythmic agent, its use is …

Relation of amiodarone hepatic and pulmonary toxicity to serum drug concentrations and superoxide dismutase activity

PT Pollak, AD Sharma, SG Carruthers - The American journal of cardiology, 1990 - Elsevier
Hepatic enzymes, pulmonary function, serum amiodarone and desethylamiodarone (DEA)
concentrations and erythrocyte superoxide dismutase (SOD) activity were monitored at …

Sudden death due to ventricular tachycardia during amiodarone therapy in familial hypertrophic cardiomyopathy

DM Gilligan, CG Missouris, MJ Boyd… - The American journal of …, 1991 - Elsevier
The potential modes of sudden death in hypertrophic cardiomyopathy (HC) can be broadly
divided into those in which arrhythmia is the primary cause and those in which initial …

Serial pulmonary function tests in patients treated with low-dose amiodarone

CS Ulrik, V Backer, J Aldershvile, AH Pietersen - American Heart Journal, 1992 - Elsevier
Problems with pulmonary toxicity have emerged as a potentially limiting factor for
amiodarone use. We studied 24 consecutive patients receiving low-dose (ie,≤ 400 mg/day) …