Highlights•MDR P. aeruginosa is one of the major causes of the nosocomial
infections.•Virulence factors involved in pathogenicity were described.•Potential inhibitors of …

Pseudomonas aeruginosa is often resistant to multiple antibiotics and consequently has
joined the ranks of 'superbugs' due to its enormous capacity to engender resistance. It …

Pseudomonas aeruginosa is a ubiquitous organism that is the focus of intense research
because of its prominent role in disease. Due to its relatively large genome and flexible …

Highlights•Environmental microorganisms are the origin of antibiotic resistance genes
acquired by human pathogens through HGT.•The use of antibiotics has selected a small …

Most bacterial pathogens have the remarkable ability to flourish in the external environment
and in specialized host niches. This ability requires their metabolism, physiology, and …

Pseudomonas aeruginosa is a metabolically versatile bacterium that is found in a wide
range of biotic and abiotic habitats. It is a major human opportunistic pathogen causing …

Antibiotic resistance is currently one of the most important public health problems. The
golden age of antibiotic discovery ended decades ago, and new approaches are urgently …

Introduction: Stenotrophomonas maltophilia is a prototype of bacteria intrinsically resistant to
antibiotics. The reduced susceptibility of this microorganism to antimicrobials mainly relies …

It is generally assumed that antibiotics and resistance determinants are the task forces of a
biological warfare in which each resistance determinant counteracts the activity of a specific …

Multidrug efflux pumps are chromosomally encoded genetic elements capable of mediating
resistance to toxic compounds in several life forms. In bacteria, these elements are involved …