Rodents are widely used to mimic human diseases to improve understanding of the causes
and progression of disease symptoms and to test potential therapeutic interventions …

The metabolic syndrome (MetS) is a cluster of risk factors including obesity, insulin
resistance, dyslipidemia, elevated blood pressure and glucose intolerance. The MetS …

That adult humans possess brown fat is now accepted—but is the brown fat metabolically
active? Does human brown fat actually combust fat to release heat? In this issue of the JCI …

Context: Recent studies examining brown adipose tissue (BAT) metabolism in adult humans
have provided convincing evidence of its thermogenic potential and role in clearing …

Indirect evidence from human studies suggests that brown adipose tissue (BAT)
thermogenesis is fueled predominantly by fatty acids hydrolyzed from intracellular …

Key points Both brown adipose tissue (BAT) and skeletal muscle activation contribute to the
metabolic response of acute cold exposure in healthy men even under minimal shivering …

The present study was designed to investigate the effects of cold on brown adipose tissue
(BAT) energy substrate utilization in vivo using the positron emission tomography tracers …

Spontaneous glucose uptake by brown adipose tissue (BAT) is lower in overweight or obese
individuals and in diabetes. However, BAT metabolism has not been previously investigated …

The epidemic of type 2 diabetes mellitus (T2DM) is fueled by added fructose consumption.
Here, we thus combined high-fat/high-fructose diet, with multiple low-dose injections of …

Summary mTORC2 controls glucose and lipid metabolism, but the mechanisms are unclear.
Here, we show that conditionally deleting the essential mTORC2 subunit Rictor in murine …