African genetic diversity and adaptation inform a precision medicine agenda
The deep evolutionary history of African populations, since the emergence of modern
humans more than 300,000 years ago, has resulted in high genetic diversity and …
humans more than 300,000 years ago, has resulted in high genetic diversity and …
The genetic overlap between mood disorders and cardiometabolic diseases: a systematic review of genome wide and candidate gene studies
AT Amare, KO Schubert, M Klingler-Hoffmann… - Translational …, 2017 - nature.com
Meta-analyses of genome-wide association studies (meta-GWASs) and candidate gene
studies have identified genetic variants associated with cardiovascular diseases, metabolic …
studies have identified genetic variants associated with cardiovascular diseases, metabolic …
Tractor uses local ancestry to enable the inclusion of admixed individuals in GWAS and to boost power
Admixed populations are routinely excluded from genomic studies due to concerns over
population structure. Here, we present a statistical framework and software package, Tractor …
population structure. Here, we present a statistical framework and software package, Tractor …
Distribution and clinical impact of functional variants in 50,726 whole-exome sequences from the DiscovEHR study
INTRODUCTION Large-scale genetic studies of integrated health care populations, with
phenotypic data captured natively in the documentation of clinical care, have the potential to …
phenotypic data captured natively in the documentation of clinical care, have the potential to …
A large electronic-health-record-based genome-wide study of serum lipids
TJ Hoffmann, E Theusch, T Haldar, DK Ranatunga… - Nature …, 2018 - nature.com
A genome-wide association study (GWAS) of 94,674 ancestrally diverse Kaiser Permanente
members using 478,866 longitudinal electronic health record (EHR)-derived measurements …
members using 478,866 longitudinal electronic health record (EHR)-derived measurements …
Identifying causal variants at loci with multiple signals of association
Although genome-wide association studies have successfully identified thousands of risk
loci for complex traits, only a handful of the biologically causal variants, responsible for …
loci for complex traits, only a handful of the biologically causal variants, responsible for …
[HTML][HTML] Harmonizing genetic ancestry and self-identified race/ethnicity in genome-wide association studies
Large-scale multi-ethnic cohorts offer unprecedented opportunities to elucidate the genetic
factors influencing complex traits related to health and disease among minority populations …
factors influencing complex traits related to health and disease among minority populations …
Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis
Background The genetic risk factors for susceptibility to chronic obstructive pulmonary
disease (COPD) are still largely unknown. Additional genetic variants are likely to be …
disease (COPD) are still largely unknown. Additional genetic variants are likely to be …
Trans-ethnic genome-wide association studies: advantages and challenges of mapping in diverse populations
YR Li, BJ Keating - Genome medicine, 2014 - Springer
Genome-wide association studies (GWASs) are the method most often used by geneticists
to interrogate the human genome, and they provide a cost-effective way to identify the …
to interrogate the human genome, and they provide a cost-effective way to identify the …
Relevance of multi-omics studies in cardiovascular diseases
P Leon-Mimila, J Wang… - Frontiers in cardiovascular …, 2019 - frontiersin.org
Cardiovascular diseases are the leading cause of death around the world. Despite the
larger number of genes and loci identified, the precise mechanisms by which these genes …
larger number of genes and loci identified, the precise mechanisms by which these genes …