Revealing the mutually enhanced mechanism of necroptosis and immunotherapy induced by defect engineering and piezoelectric effect

Y Du, J Yang, F He, X Zhao, J Zhou, P Zang… - Advanced …, 2024 - Wiley Online Library
Owing to low immunogenicity‐induced immune escape and short‐term circulating immune
responses, the efficiency of immunotherapy is unsatisfactory. Therefore, triggering …

Light‐responsive inorganic biomaterials for biomedical applications

HP Lee, AK Gaharwar - Advanced science, 2020 - Wiley Online Library
Light‐responsive inorganic biomaterials are an emerging class of materials used for
developing noninvasive, noncontact, precise, and controllable medical devices in a wide …

Second near‐infrared light‐activatable polymeric nanoantagonist for photothermal immunometabolic cancer therapy

C Xu, Y Jiang, J Huang, J Huang, K Pu - Advanced Materials, 2021 - Wiley Online Library
Immunometabolic modulation offers new opportunities to treat cancers as it is highly
associated with cancer progression and immunosuppressive microenvironment. However …

MnOx Nanospikes as Nanoadjuvants and Immunogenic Cell Death Drugs with Enhanced Antitumor Immunity and Antimetastatic Effect

B Ding, P Zheng, F Jiang, Y Zhao… - Angewandte Chemie …, 2020 - Wiley Online Library
Despite the widespread applications of manganese oxide nanomaterials (MONs) in
biomedicine, the intrinsic immunogenicity of MONs is still unclear. MnOx nanospikes (NSs) …

Reactive oxygen species-powered cancer immunotherapy: Current status and challenges

M He, M Wang, T Xu, M Zhang, H Dai, C Wang… - Journal of Controlled …, 2023 - Elsevier
Reactive oxygen species (ROS) are crucial signaling molecules that can arouse immune
system. In recent decades, ROS has emerged as a unique therapeutic strategy for malignant …

Engineered nanoparticles for cancer vaccination and immunotherapy

ME Aikins, C Xu, JJ Moon - Accounts of chemical research, 2020 - ACS Publications
Conspectus The immune system has evolved over time to protect the host from foreign
microorganisms. Activation of the immune system is predicated on a distinction between self …

A mesoporous nanoenzyme derived from metal–organic frameworks with endogenous oxygen generation to alleviate tumor hypoxia for significantly enhanced …

D Wang, H Wu, WQ Lim, SZF Phua, P Xu… - Advanced …, 2019 - Wiley Online Library
Tumor hypoxia compromises the therapeutic efficiency of photodynamic therapy (PDT) as
the local oxygen concentration plays an important role in the generation of cytotoxic singlet …

Na2S2O8 Nanoparticles Trigger Antitumor Immunotherapy through Reactive Oxygen Species Storm and Surge of Tumor Osmolarity

Y Liu, W Zhen, Y Wang, S Song… - Journal of the American …, 2020 - ACS Publications
Although more attention has been attracted to the therapy based on reactive oxygen species
(ROS) for tumor therapy in recent years, such as photodynamic therapy and chemodynamic …

Photodynamic therapy: photosensitizers and nanostructures

A Escudero, C Carrillo-Carrión… - Materials Chemistry …, 2021 - pubs.rsc.org
The reactions of some structures to different external stimuli can be used for therapeutic
purposes. In particular, in photodynamic therapy (PDT), a light-sensitive compound or …

Electromagnetic nanomedicines for combinational cancer immunotherapy

J Li, Y Luo, K Pu - Angewandte Chemie International Edition, 2021 - Wiley Online Library
Immunotherapy that harnesses the power of the immune system to eliminate malignant cells
has offered an effective approach for cancer treatment. However, limited patient response …