Background Severe trauma represents a major global public health burden and the
management of post-traumatic bleeding continues to challenge healthcare systems around …

Irrespective of the reason for hypoperfusion, hypocoagulable and/or hyperfibrinolytic
hemostatic aberrancies afflict up to one-quarter of critically ill patients in shock. Intensivists …

Importance Hemorrhagic shock is a common cause of preventable death after injury.
Vasopressor administration for patients with blunt trauma and hemorrhagic shock is often …

Massive trauma remains a leading cause of death and a global public health burden. Post-
traumatic coagulopathy may be present even before the onset of resuscitation, and …

Traumatic brain injury (TBI) is heterogeneous, effects all populations worldwide, and spares
no age groups. 1 Identifying and halting ongoing effects of the primary trauma, preventing …

Uncontrolled and massive bleeding with derangement of coagulation is a major challenge in
the management of both surgical and seriously injured patients. The underlying mechanism …

Patients with massive hemorrhage require a nuanced resuscitation to maintain circulation
and achieve hemostasis. Massive transfusion (MT) forms the central core of this …

Background The trauma mortality rate is higher in the elderly compared with younger
patients. Ageing is associated with physiological changes in multiple systems and correlated …

The fifth edition of the European guidelines on management of major bleeding and
coagulopathy after trauma recommends the use of vasopressors in addition to fluids to …

Background and Objectives: C-clamp application may reduce mortality in patients with
unstable pelvic fractures and hemodynamic instability. Decreasing C-clamp use over the …