Rational chemical design of molecular glue degraders
ES Toriki, JW Papatzimas, K Nishikawa… - ACS Central …, 2023 - ACS Publications
Targeted protein degradation with molecular glue degraders has arisen as a powerful
therapeutic modality for eliminating classically undruggable disease-causing proteins …
therapeutic modality for eliminating classically undruggable disease-causing proteins …
Mathematical Model for Covalent Proteolysis Targeting Chimeras: Thermodynamics and Kinetics Underlying Catalytic Efficiency
C Chaudhry - Journal of Medicinal Chemistry, 2023 - ACS Publications
Proteolysis targeting chimeras (PROTACs), heterobifunctional protein degraders, have
emerged as an exciting and transformative technology in chemical biology and drug …
emerged as an exciting and transformative technology in chemical biology and drug …
Proximity-Based Modalities for Biology and Medicine
Molecular proximity orchestrates biological function, and blocking existing proximities is an
established therapeutic strategy. By contrast, strengthening or creating neoproximity with …
established therapeutic strategy. By contrast, strengthening or creating neoproximity with …
Pooled endogenous protein tagging and recruitment for scalable discovery of effectors for induced proximity therapeutics
The field of induced proximity therapeutics is in its ascendancy but is limited by a lack of
scalable tools to systematically explore effector-target protein pairs in an unbiased manner …
scalable tools to systematically explore effector-target protein pairs in an unbiased manner …