Background Antidepressant discontinuation symptoms are becoming an increasingly
important part of clinical practice, but the incidence of antidepressant discontinuation …

Concurrent with recent insights into the neuroprogressive nature of depression, ketamine
shows promise in interfering with several neuroprogressive factors, and has been suggested …

We thank the authors of all the letters for their interest in our paper [1]. The reason our paper
is important is that the pharmaceutical industry, along with many doctors and academics …

Major depressive disorder is one of the most severe mental disorders. It strongly impairs
daily functioning, and, in extreme cases, it can lead to suicide. Although different treatment …

Approximately half of the tens of millions of people currently taking antidepressants will
experience withdrawal symptoms when they try to reduce or come off them. Nearly half of …

Background Many people experience withdrawal symptoms when they attempt to stop
antidepressants. Withdrawal symptoms are readily misconstrued for relapse or ongoing …

Background Stopping long-term (> 12 months) antidepressant use can be difficult due to
unpleasant withdrawal symptoms. Many people do not recognise withdrawal symptoms or …

The term dependence has come to be used interchangeably with addiction in common
language. 1 This conflation originates from the use of the word dependence to describe …

Background Our knowledge of the broader impacts of antidepressant withdrawal, beyond
physical side effects, is limited. Further research is needed to investigate the lived …

BACKGROUND: Depression drugs can be difficult to come off due to withdrawal symptoms.
Gradual tapering with tapering support is needed to help patients withdraw safely …