In addition to their role in binding antigen, antibodies can regulate immune responses
through interacting with Fc receptors (FcRs). In recent years, significant progress has been …

The spreading epidemic of allergies and asthma has heightened interest in IgE, the central
player in the allergic response. The activity of IgE is associated with a network of proteins; …

The immune response depends on the binding of opsonized antigens to cellular Fc
receptors and the subsequent initiation of various cellular effector functions of the immune …

Allergic individuals exposed to minute quantities of allergen experience an immediate
response. Immediate hypersensitivity reflects the permanent sensitization of mucosal mast …

The FcεRI complex forms a high-affinity cell-surface receptor for the Fc region of antigen-
specific immunoglobulin E (IgE) molecules. FcεRI is multimeric and is a member of a family …

The high-affinity Fc receptor for IgE (FcεRI), a multimeric immune receptor, is a crucial
structure for IgE-mediated allergic reactions. In recent years, advances have been made in …

Immunoglobulins couple the recognition of invading pathogens with the triggering of potent
effector mechanisms for pathogen elimination. Different immunoglobulin classes trigger …

Mast cells and basophils are important effector cells in T helper 2 (TH2)-cell-dependent,
immunoglobulin-E-associated allergic disorders and immune responses to parasites. The …

Fcγ receptors mediate antibody-dependent inflammatory responses and cytotoxicity as well
as certain autoimmune dysfunctions. Here we report the crystal structure of a human Fc …

The initiation of immunoglobulin-E (IgE)-mediated allergic responses requires the binding of
IgE antibody to its high-affinity receptor, FcεRI. Crosslinking of FcεRI initiates an intracellular …