The most common drawback of the existing and novel drug molecules is their low
bioavailability because of their low solubility. One of the most important approaches to …

The persistence of amorphous atorvastatin calcium has been studied as a function of the
amorphization method, polymer content, and relative humidity during storage. For …

Despite the fact that an amorphous solid dispersion (ASD)-coated pellet formulation offers
potential advantages regarding the minimization of physical stability issues, there is still a …

Spray drying is one of the most commonly used manufacturing techniques for amorphous
solid dispersions (ASDs). During spray drying, very fast solvent evaporation is enabled by …

The number of drug molecules that show poor aqueous solubility and low dissolution rate
has significantly increased during the past two decades, resulting in low oral bioavailability …

A drawback of the current drug selection procedures is their high output of drug candidates
with unfavorable physicochemical properties12. More specifically, ca. 70% of new drug …