Cell–cell junctions link cells to each other in tissues, and regulate tissue homeostasis in
critical cell processes that include tissue barrier function, cell proliferation, and migration …

Tissue and organ development during embryogenesis relies on the collective and
coordinated action of many cells. Recent studies have revealed that tissue material …

Epithelial-mesenchymal transition (EMT) is strongly implicated in tumor cell invasion and
metastasis. EMT is thought to be regulated primarily at the transcriptional level through the …

E-cadherin is a single-pass transmembrane protein that mediates homophilic cell–cell
interactions. Tumour progression is often associated with the loss of E-cadherin function and …

Cadherins are homophilic adhesion molecules with important functions in cell-cell adhesion,
tissue morphogenesis, and cancer. In epithelial cells, E-cadherin accumulates at areas of …

How adhesive interactions between cells generate and maintain animal tissue structure
remains one of the most challenging and long-standing questions in cell and developmental …

The metastatic process, ie the dissemination of cancer cells throughout the body to seed
secondary tumors at distant sites, requires cancer cells to leave the primary tumor and to …

This review is dedicated to E-cadherin, a calcium-dependent cell-cell adhesion molecule
with pivotal roles in epithelial cell behavior, tissue formation, and suppression of cancer. As …

Intercellular junctions mediate adhesion and communication between adjoining endothelial
and epithelial cells. In the endothelium, junctional complexes comprise tight junctions …

Inflammatory bowel disease (IBD) is a multifactorial disease. A breach in the mucosal
barrier, otherwise known as “leaky gut,” is alleged to promote mucosal inflammation by …