The human intestine, which harbors trillions of symbiotic microorganisms, may enter into
dysbiosis when exposed to a genetic defect or environmental stress. The naissance of …

Objective Genetic and environmental factors influence pathogenesis and rising incidence of
paediatric inflammatory bowel disease (PIBD). The aim was to meta‐analyse evidence of …

Background Stricturing, penetrating complications and extraintestinal manifestations (EIMs)
are frequent in patients with inflammatory bowel disease (IBD). There is limited data on the …

Background and objective Appendectomy may modulate the risk of inflammatory bowel
disease through an effect on the gut microbiota. This study investigated the associations …

Background Recent advances in the management of inflammatory bowel disease (IBD)
striving for new treatment targets may have decreased rates of hospitalization for flares. We …

Introduction There is an urgent need to understand the long-term real-world effectiveness of
ustekinumab (UST) in the treatment of Crohn's disease (CD), fistulizing CD (FCD), and …

Immunomodulators such as tumour necrosis factor (TNF) inhibitors are used to treat
autoimmune conditions by reducing the magnitude of the innate immune response …

Background There are differences in the efficacy and safety profiles of medications used to
treat IBD that may impact a woman's perceived risk of medication exposure during …

A nonmedical switch policy is currently being considered in Alberta, which would force
patients on originator biologics to biosimilar alternatives with the hypothetical aim of …

Abstract Background Inflammatory bowel diseases (IBDs) are chronic gastrointestinal
diseases that negatively affect the enjoyment of food and engagement in social and cultural …