Plasma biomarkers of inflammation, the kynurenine pathway, and risks of all-cause, cancer, and cardiovascular disease mortality: the Hordaland Health Study
We aimed to evaluate 10 biomarkers related to inflammation and the kynurenine pathway,
including neopterin, kynurenine: tryptophan ratio, C-reactive protein, tryptophan, and 6 …
including neopterin, kynurenine: tryptophan ratio, C-reactive protein, tryptophan, and 6 …
[HTML][HTML] Cancer cell metabolic reprogramming: a keystone for the response to immunotherapy
M Cerezo, S Rocchi - Cell Death & Disease, 2020 - nature.com
By targeting the tumor microenvironment to stimulate antitumor immunity, immunotherapies
have revolutionized cancer treatment. However, many patients do not respond initially or …
have revolutionized cancer treatment. However, many patients do not respond initially or …
The kynurenine pathway in major depression: What we know and where to next
Major depression is a serious psychiatric disorder, occurring in up to 20% of the population.
Despite its devastating burden, the neurobiological changes associated with depression are …
Despite its devastating burden, the neurobiological changes associated with depression are …
Immunosenescence and inflamm-ageing in COVID-19
The destructive effects of coronavirus disease 2019 (COVID-19) on the elderly and people
with cardiovascular disease have been proven. New findings shed light on the role of aging …
with cardiovascular disease have been proven. New findings shed light on the role of aging …
[PDF][PDF] Exercise and the Kynurenine pathway: Current state of knowledge and results from a randomized cross-over study comparing acute effects of endurance and …
N Joisten, F Kummerhoff, C Koliamitra… - Exercise immunology …, 2020 - eir-isei.de
Introduction: The essential amino acid tryptophan (TRP) is primarily degraded through the
kynurenine (KYN) pathway, which is dysregulated in several chronic diseases. KYN …
kynurenine (KYN) pathway, which is dysregulated in several chronic diseases. KYN …
[HTML][HTML] Probiotic supplements beneficially affect tryptophan–kynurenine metabolism and reduce the incidence of upper respiratory tract infections in trained athletes …
B Strasser, D Geiger, M Schauer, JM Gostner… - Nutrients, 2016 - mdpi.com
Background: Prolonged intense exercise has been associated with transient suppression of
immune function and an increased risk of infections. In this context, the catabolism of amino …
immune function and an increased risk of infections. In this context, the catabolism of amino …
[HTML][HTML] The role of tryptophan metabolites in neuropsychiatric disorders
In recent decades, neuropsychiatric disorders such as major depressive disorder,
schizophrenia, bipolar, etc., have become a global health concern, causing various …
schizophrenia, bipolar, etc., have become a global health concern, causing various …
Association between diffusion tensor imaging, inflammation and immunological alterations in unipolar and bipolar depression: a review
Abstract Major Depressive Disorder (MDD) and Bipolar Disorder Depression (BDD) are
common psychiatric illnesses characterized by structural and functional brain alterations and …
common psychiatric illnesses characterized by structural and functional brain alterations and …
An aryl hydrocarbon receptor-mediated amplification loop that enforces cell migration in ER−/PR−/Her2− human breast cancer cells
O Novikov, Z Wang, EA Stanford, AJ Parks… - Molecular …, 2016 - ASPET
The endogenous ligand-activated aryl hydrocarbon receptor (AHR) plays an important role
in numerous biologic processes. As the known number of AHR-mediated processes grows …
in numerous biologic processes. As the known number of AHR-mediated processes grows …
[HTML][HTML] Current evidence for a role of the kynurenine pathway of tryptophan metabolism in multiple sclerosis
MD Lovelace, B Varney, G Sundaram… - Frontiers in …, 2016 - frontiersin.org
The kynurenine pathway (KP) is the major metabolic pathway of the essential amino acid
tryptophan (TRP). Stimulation by inflammatory molecules, such as interferon-γ (IFN-γ), is the …
tryptophan (TRP). Stimulation by inflammatory molecules, such as interferon-γ (IFN-γ), is the …