[HTML][HTML] Pathobiological mechanisms underlying metabolic syndrome (MetS) in chronic obstructive pulmonary disease (COPD): clinical significance and therapeutic …
Chronic obstructive pulmonary disease (COPD) is a major incurable global health burden
and is currently the 4th largest cause of death in the world. Importantly, much of the disease …
and is currently the 4th largest cause of death in the world. Importantly, much of the disease …
The preclinical pharmacology of roflumilast–a selective, oral phosphodiesterase 4 inhibitor in development for chronic obstructive pulmonary disease
A Hatzelmann, EJ Morcillo, G Lungarella… - Pulmonary …, 2010 - Elsevier
After more than two decades of research into phosphodiesterase 4 (PDE4) inhibitors,
roflumilast (3-cyclopropylmethoxy-4-difluoromethoxy-N-[3, 5-di-chloropyrid-4-yl]-benzamide) …
roflumilast (3-cyclopropylmethoxy-4-difluoromethoxy-N-[3, 5-di-chloropyrid-4-yl]-benzamide) …
Physical activity is the strongest predictor of all-cause mortality in patients with COPD: a prospective cohort study
B Waschki, A Kirsten, O Holz, KC Müller, T Meyer… - Chest, 2011 - Elsevier
Background Systemic effects of COPD are incompletely reflected by established prognostic
assessments. We determined the prognostic value of objectively measured physical activity …
assessments. We determined the prognostic value of objectively measured physical activity …
Beyond BMI: obesity and lung disease
The worldwide prevalence of obesity has increased rapidly in the last 3 decades, and this
increase has led to important changes in the pathogenesis and clinical presentation of many …
increase has led to important changes in the pathogenesis and clinical presentation of many …
Cytokine inhibition in the treatment of COPD
G Caramori, IM Adcock, A Di Stefano… - International journal of …, 2014 - Taylor & Francis
Cytokines play an important part in many pathobiological processes of chronic obstructive
pulmonary disease (COPD), including the chronic inflammatory process, emphysema, and …
pulmonary disease (COPD), including the chronic inflammatory process, emphysema, and …
Adiponectin in inflammatory and immune-mediated diseases
G Fantuzzi - Cytokine, 2013 - Elsevier
Circulating levels of adiponectin (APN) are reduced in obesity and associated comorbidities,
with inflammation playing an important role in downregulating APN production. In contrast to …
with inflammation playing an important role in downregulating APN production. In contrast to …
A systematic review of diagnostic biomarkers of COPD exacerbation
YWR Chen, JM Leung, DD Sin - PloS one, 2016 - journals.plos.org
The aims of this systematic review were to determine which blood-based molecules have
been evaluated as possible biomarkers to diagnose chronic obstructive pulmonary disease …
been evaluated as possible biomarkers to diagnose chronic obstructive pulmonary disease …
COPD association and repeatability of blood biomarkers in the ECLIPSE cohort
JA Dickens, BE Miller, LD Edwards, EK Silverman… - Respiratory …, 2011 - Springer
Background There is a need for biomarkers to better characterise individuals with COPD
and to aid with the development of therapeutic interventions. A panel of putative blood …
and to aid with the development of therapeutic interventions. A panel of putative blood …
Systemic inflammation in chronic obstructive pulmonary disease: may adipose tissue play a role? Review of the literature and future perspectives
R Tkacova - Mediators of inflammation, 2010 - Wiley Online Library
Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality
worldwide. Low‐grade systemic inflammation is considered a hallmark of COPD that …
worldwide. Low‐grade systemic inflammation is considered a hallmark of COPD that …
Leptin, adiponectin and pulmonary diseases
NA Assad, A Sood - Biochimie, 2012 - Elsevier
Adipose tissue produces leptin and adiponectin–energy-regulating adipokines that may also
play a role in inflammatory pulmonary conditions, as suggested by some murine studies …
play a role in inflammatory pulmonary conditions, as suggested by some murine studies …