Aging and neurodegenerative diseases share common hallmarks, including mitochondrial
dysfunction and protein aggregation. Moreover, one of the major issues of the demographic …

Oxidative stress has been proposed to be an important factor in the pathogenesis of
Alzheimer's disease (AD) and contributed to β-amyloid (A β) generation. Interaction between …

Several epidemiological studies show an inverse association between cancer and
Alzheimer's disease (AD). It is debated whether this association is the consequence of …

Alzheimer's disease (AD) is a neurodegenerative disorder with no clear causative event
making the disease difficult to diagnose and treat. The pathological hallmarks of AD include …

More than 100 years after description of Alzheimer's disease (AD), two major pathological
processes observed already by Alois Alzheimer, remain as the main explanation of the …

Alzheimer's Disease (AD) and Type 2 diabetes mellitus (T2DM) are two incurable diseases
both hallmarked by an abnormal deposition of the amyloidogenic peptides Aβ and Islet …

AMP-activated protein kinase (AMPK), a master regulator of cellular energy homeostasis
and a central player in glucose and lipid metabolism, is potentially implicated in the …

Alzheimer's disease (AD) is the general consequence of dementia and is diagnostic
neuropathology by the cumulation of amyloid-beta (Aβ) protein aggregates, which are …

Amyloid precursor protein (APP) is a member of the APP family of proteins, and different
enzymatic processing leads to the production of several derivatives that are shown to have …

Neurodegenerative diseases are still a challenge for effective treatments. The high cost of
approved drugs, severity of side effects, injection site pain, and restrictions on drug delivery …