[HTML][HTML] Targeted protein degradation: clinical advances in the field of oncology
AKAA Salama, MV Trkulja, E Casanova… - International Journal of …, 2022 - mdpi.com
The field of targeted protein degradation (TPD) is a rapidly developing therapeutic modality
with the promise to tame disease-relevant proteins in ways that are difficult or impossible to …
with the promise to tame disease-relevant proteins in ways that are difficult or impossible to …
Unveiling the role of host kinases at different steps of influenza A virus life cycle
Influenza viruses remain a major public health concern causing contagious respiratory
illnesses that result in around 290,000–650,000 global deaths every year. Their ability to …
illnesses that result in around 290,000–650,000 global deaths every year. Their ability to …
[HTML][HTML] Neuroprotective effects of chaperone-mediated autophagy in neurodegenerative diseases
Q Jia, J Li, X Guo, Y Li, Y Wu, Y Peng… - Neural Regeneration …, 2024 - journals.lww.com
Chaperone-mediated autophagy is one of three types of autophagy and is characterized by
the selective degradation of proteins. Chaperone-mediated autophagy contributes to energy …
the selective degradation of proteins. Chaperone-mediated autophagy contributes to energy …
Putative Looping Factor ZNF143/ZFP143 is an Essential Transcriptional Regulator with No Looping Function
DN Narducci, AS Hansen - bioRxiv, 2024 - biorxiv.org
Interactions between distal loci, including those involving enhancers and promoters, are a
central mechanism of gene regulation in mammals, yet the protein regulators of these …
central mechanism of gene regulation in mammals, yet the protein regulators of these …
Bruton Tyrosine Kinase Degraders in B-Cell Malignancies
T Huynh, S Rodriguez-Rodriguez, AV Danilov - Molecular Cancer …, 2024 - AACR
Bruton tyrosine kinase (BTK) belongs to the TEC family of nonreceptor kinases and is
expressed in various hematopoietic cells, including B cells, myeloid cells, and platelets (1) …
expressed in various hematopoietic cells, including B cells, myeloid cells, and platelets (1) …
Enhancing cell‐based therapies with synthetic gene circuits responsive to molecular stimuli
S Galvan, AP Teixeira… - Biotechnology and …, 2024 - Wiley Online Library
Synthetic biology aims to contribute to the development of next‐generation patient‐specific
cell‐based therapies for chronic diseases especially through the construction of …
cell‐based therapies for chronic diseases especially through the construction of …
[HTML][HTML] Cumulus Cells Accelerate Postovulatory Oocyte Aging through IL1–IL1R1 Interaction in Mice
X Wen, Q Yang, D Sun, ZY Jiang, T Wang… - International Journal of …, 2023 - mdpi.com
The oocytes of female mammals will undergo aging after ovulation, also known as
postovulatory oocyte aging (POA). Until now, the mechanisms of POA have not been fully …
postovulatory oocyte aging (POA). Until now, the mechanisms of POA have not been fully …
分子伴侣介导自噬的神经保护作用
Q Jia, J Li, X Guo, Y Li, Y Wu, Y Peng, Z Fang… - 中国神经再生研究 …, 2024 - sjzsyj.com.cn
分子伴侣介导的自噬是3 种自噬中的之一, 其特征是选择性降解蛋白质. 分子伴侣介导的自噬有
助于维持能量平衡及细胞内稳态, 同时也能为细胞生存提供营养和支持. 包括神经元在内几乎 …
助于维持能量平衡及细胞内稳态, 同时也能为细胞生存提供营养和支持. 包括神经元在内几乎 …