The term 'fibroblast'often serves as a catch-all for a diverse array of mesenchymal cells,
including perivascular cells, stromal progenitor cells and bona fide fibroblasts. Although …

Over the past decade, RAS oncogenic proteins have transitioned from being deemed
undruggable to having two clinically approved drugs, with several more in advanced stages …

Fibroblasts are present throughout the body and function to maintain tissue homeostasis.
Recent studies have identified diverse fibroblast subsets in healthy and injured tissues,, but …

Cancer stem cells (CSCs), a small subset of cells in tumors that are characterized by self-
renewal and continuous proliferation, lead to tumorigenesis, metastasis, and maintain tumor …

NF-κB signaling has been discovered for nearly 40 years. Initially, NF-κB signaling was
identified as a pivotal pathway in mediating inflammatory responses. However, with …

Cellular homeostasis is intricately influenced by stimuli from the microenvironment, including
signaling molecules, metabolites, and pathogens. Functioning as a signaling hub within the …

The skin is the most-extensive and-abundant tissue in the human body. Like many organs,
as we age, human skin experiences gradual atrophy in both the epidermis and dermis. This …

This review explores the mechanisms of chronic radiation-induced skin injury fibrosis,
focusing on the transition from acute radiation damage to a chronic fibrotic state. It reviewed …

Background Tumor heterogeneity presents a formidable challenge in understanding the
mechanisms driving tumor progression and metastasis. The heterogeneity of hepatocellular …

Skin wounds are common in accidental injuries, and the intricacies of wound repair are
closely linked to endogenous electric fields. Electrical stimulation plays a pivotal role in the …