The strategy of using existing drugs originally developed for one disease to treat other
indications has found success across medical fields. Such drug repurposing promises faster …

While cancer is commonly described as “a disease of the genes”, it is also a disease of
metabolism. Indeed, carcinogenesis and malignancy are highly associated with metabolic re …

Abstract Background/Purpose Type 2 diabetes and obesity increase the risk of developing
colorectal cancer. Metformin may reduce colorectal cancer but the mechanisms mediating …

Emerging evidence reveals that adipose tissue-associated inflammation is a main
mechanism whereby obesity promotes colorectal cancer risk and progression. Increased …

Purpose There has been an alarming increase in colorectal cancer (CRC) incidence among
young adults aged< 50 years, and factors driving this upward trend are unknown. This study …

Diabetes mellitus (DM) and hyperglycemia have been shown to have significant effects on
the incidence, chemoresistance, and prognosis of colorectal cancer (CRC), as well as the …

Abstract Background and Aims The association between obesity and colorectal cancer
(CRC) is well established in older individuals, but evidence is limited in the younger …

Opinion statement Diabetes mellitus (DM) can affect the structure and function of the colon
promoting commonly encountered lower gastrointestinal symptoms such as constipation …

Objective Colorectal cancer (CRC) leads to significant morbidity/mortality worldwide.
Defining critical research gaps (RG), their prioritisation and resolution, could improve patient …

Diabetes is a common metabolic disorder that has become a major health problem
worldwide. In this study, we investigated the role of rutin in attenuating diabetes and …