The development of therapeutic approaches for the induction of robust, long-lasting and
antigen-specific immune tolerance remains an important unmet clinical need for the …

A wide variety and large number of bacterial species live in the gut, forming the gut
microbiota. Gut microbiota not only coexist harmoniously with their hosts, but they also …

Infusion of T cells engineered to express chimeric antigen receptors (CARs) that target B
cells has proven to be a successful treatment for B cell malignancies. This success inspired …

CD4+ CD25hiCD127lo/− FOXP3+ regulatory T cells (Tregs) play a key role in preventing
autoimmunity. In autoimmune type 1 diabetes (T1D), adoptive transfer of autologous …

In the past two decades, a significant number of studies have been published describing the
molecular and clinical aspects of Immune dysregulation Polyendocrinopathy Enteropathy X …

Parkinson's disease (PD) stands as the second most common neurodegenerative disorder
after Alzheimer's disease, and its prevalence continues to rise with the aging global …

Mouse models have been instrumental in understanding mechanisms of transplant rejection
and tolerance, but cross-study reproducibility and translation of experimental findings into …

Autoimmune diseases can damage specific or multiple organs and tissues, influence the
quality of life, and even cause disability and death. A 'disease in a dish'can be developed …

Adeno-associated virus (AAV) gene therapy is making rapid strides owing to its wide range
of therapeutic applications. However, development of serious immune responses to the …

Regulatory T cells (Tregs) are essential for maintaining the immune balance in normal and
pathological conditions. In autoimmune diseases and transplantation, they restrain the loss …