Blood platelets and sepsis pathophysiology: a new therapeutic prospect in critical ill patients?

A Dewitte, S Lepreux, J Villeneuve, C Rigothier… - Annals of intensive …, 2017 - Springer
Beyond haemostasis, platelets have emerged as versatile effectors of the immune response.
The contribution of platelets in inflammation, tissue integrity and defence against infections …

Revisiting platelets and toll-like receptors (TLRs): at the interface of vascular immunity and thrombosis

K Hally, S Fauteux-Daniel… - International journal of …, 2020 - mdpi.com
While platelet function has traditionally been described in the context of maintaining
vascular integrity, recent evidence suggests that platelets can modulate inflammation in a …

Cathelicidins prime platelets to mediate arterial thrombosis and tissue inflammation

J Pircher, T Czermak, A Ehrlich, C Eberle… - Nature …, 2018 - nature.com
Leukocyte-released antimicrobial peptides contribute to pathogen elimination and activation
of the immune system. Their role in thrombosis is incompletely understood. Here we show …

Sialylated glycan bindings from SARS-CoV-2 spike protein to blood and endothelial cells govern the severe morbidities of COVID-19

DE Scheim, P Vottero, AD Santin, AG Hirsh - International journal of …, 2023 - mdpi.com
Consistent with well-established biochemical properties of coronaviruses, sialylated glycan
attachments between SARS-CoV-2 spike protein (SP) and host cells are key to the virus's …

Influenza-induced thrombocytopenia is dependent on the subtype and sialoglycan receptor and increases with virus pathogenicity

AJG Jansen, T Spaan, HZ Low, D Di Iorio… - Blood …, 2020 - ashpublications.org
Thrombocytopenia is a common complication of influenza virus infection, and its severity
predicts the clinical outcome of critically ill patients. The underlying cause (s) remain …

A deadly embrace: Hemagglutination mediated by SARS-CoV-2 spike protein at its 22 N-glycosylation sites, red blood cell surface sialoglycoproteins, and antibody

DE Scheim - International journal of molecular sciences, 2022 - mdpi.com
Rouleaux (stacked clumps) of red blood cells (RBCs) observed in the blood of COVID-19
patients in three studies call attention to the properties of several enveloped virus strains …

Translational implications of platelets as vascular first responders

RC Becker, T Sexton, SS Smyth - Circulation research, 2018 - Am Heart Assoc
Platelets play a vital role in normal hemostasis to stem blood loss at sites of vascular injury
by tethering and adhering to sites of injury, recruiting other platelets and blood cells to the …

Role of extracellular vesicles in the development of sepsis-induced coagulopathy

T Iba, H Ogura - Journal of Intensive Care, 2018 - Springer
Background The advances of research on extracellular vesicles (EVs) are of particular
interest to the clinicians as well as the researchers who are studying coagulation disorder in …

From blood coagulation to innate and adaptive immunity: the role of platelets in the physiology and pathology of autoimmune disorders

ZM Łukasik, M Makowski, JS Makowska - Rheumatology international, 2018 - Springer
Thrombosis and cardiovascular complications are common manifestations of a variety of
pathological conditions, including infections and chronic inflammatory diseases. Hence …

[HTML][HTML] Histological comparison of arterial thrombi in mice and men and the influence of Cl-amidine on thrombus formation

J Novotny, S Chandraratne, T Weinberger, V Philippi… - PloS one, 2018 - journals.plos.org
Aims Medical treatment of arterial thrombosis is mainly directed against platelets and
coagulation factors, and can lead to bleeding complications. Novel antithrombotic therapies …