There have been many ups and downs since the introduction of gene therapy as a
therapeutic modality for diseases. However, the journey of gene therapy has reached a …

With the advent of recombinant DNA technology in the 1970s, the idea of using gene
therapies to treat human genetic diseases captured the interest and imagination of scientists …

Cancer stands as one of the most leading causes of death worldwide, while one of the most
significant challenges in treating it is revealing novel alternatives to predict, diagnose, and …

In recent years, nanomaterials have been widely applied as advanced drug and gene
delivery nanosystems. Among them, solid lipid nanoparticles (SLNs) have attracted great …

MicroRNAs (miRNAs) are small double-stranded RNAs that exert a fine-tuning sequence-
specific regulation of cell transcriptome. While one unique miRNA regulates hundreds of …

Alzheimer's disease (AD) is a chronic dysfunction of neurons in the brain leading to
dementia. It is characterized by gradual mental failure, abnormal cognitive functioning …

Inherited retinal diseases (IRDs) are both genetically and clinically highly heterogeneous
and have long been considered incurable. Following the successful development of a gene …

Background Nanoinjection—the process of intracellular delivery using vertically configured
nanostructures—is a physical route that efficiently negotiates the plasma membrane, with …

Glaucoma, an age-related neurodegenerative disease, is characterized by the death of
retinal ganglion cells (RGCs) and the corresponding loss of visual fields. This disease is the …

Gene delivery systems necessitate the gene therapy, which is a unique approach for
applying the tunable genes to treat any diseases. To tackle down the disadvantages of viral …