Provided herein are compositions and methods for disrupting at least one reward-related
behavior in an individual through the use of light-responsive opsin proteins used to control …

Lung cancer is the leading cause of cancer-related mortality with about 1.6 million deaths
every year worldwide. Gene mutations and overexpression of oncogenes play a central role …

Various aspects are directed to systems and methods for assessing neural activity of a
neural region having multiple subfields. In certain embodiments, a method includes evoking …

Aim: Improving the delivery of siRNA into cancer cells via bubble liposomes. Designing a
thermoresponsive pegylated liposome through the introduction of ammonium bicarbonate …

Plasmid DNA-encoded antibodies, or DNA-based monoclonal antibodies (dMAbs), are
delivered by intramuscular injection and in vivo electroporation (EP) and are effective in …

β-Thalassemia is an inherited hematological disorder that results from genetic changes in
the β-globin gene, leading to the reduced or absent synthesis of β-globin. For several …

Gene therapy has shown great potential for the treatment of diseases that previously were
either untreatable or treatable but not curable with conventional schemes. Recent progress …

We used magnetofection (MF) to achieve high transfection efficiency into human
mesenchymal stem cells (MSCs). A custom-made magnet array, matching well-to-well to a …

There are many clinical trials underway for the development of gene therapies, and some
have resulted in gene therapy products being commercially approved already. Significant …

Elevated intraocular pressure (IOP) in glaucoma causes retinal ganglion cell (RGC) loss and
damage to the optic nerve. Although IOP is controlled pharmacologically, no treatment is …