In the past 15 years, B cells have been rediscovered to be not merely bystanders but rather
active participants in autoimmune aetiology. This has been fuelled in part by the clinical …

Experimental autoimmune encephalomyelitis (EAE) is the most commonly used
experimental model for the human inflammatory demyelinating disease, multiple sclerosis …

B cells have an ever-increasing role in the etiopathology of a number of autoimmune
neurological disorders, acting as antigen-presenting cells facilitating antibody production but …

The high failure rate of immunotherapies in multiple sclerosis (MS) clinical trials
demonstrates problems in translating new treatment concepts from animal models to the …

In recent years, the role of B cells in neurological disorders has substantially expanded our
perspectives on mechanisms of neuroinflammation. The success of B cell-depleting …

Multiple Sclerosis (MS) is an inflammatory demyelinating disease of the central nervous
system. Once thought to be primarily driven by T cells, B cells are emerging as central …

Little is known about the role of IL-3 in multiple sclerosis (MS) in humans and in
experimental autoimmune encephalomyelitis (EAE). Using myelin oligodendrocyte …

The success of selective B-cells depleting therapies, as the anti-CD20 antibodies, in patients
with multiple sclerosis (MS) has confirmed that B-cells are critical in the immune …

While it was long held that T cells were the primary mediators of multiple sclerosis (MS)
pathogenesis, the beneficial effects observed in response to treatment with Rituximab (RTX) …

EBV is the major infectious environmental risk factor for multiple sclerosis (MS), but the
underlying mechanisms remain obscure. Patient studies do not allow manipulation in vivo …