Microglia-mediated neuroinflammation and neuroplasticity after stroke

Y Wang, RK Leak, G Cao - Frontiers in cellular neuroscience, 2022 - frontiersin.org
Stroke remains a major cause of long-term disability and mortality worldwide. The immune
system plays an important role in determining the condition of the brain following stroke. As …

Potential role of natural antioxidants in countering reperfusion injury in acute myocardial infarction and ischemic stroke

S Orellana-Urzúa, C Briones-Valdivieso, S Chichiarelli… - Antioxidants, 2023 - mdpi.com
Stroke and acute myocardial infarction are leading causes of mortality worldwide. The latter
accounts for approximately 9 million deaths annually. In turn, ischemic stroke is a significant …

Activating cGAS–STING axis contributes to neuroinflammation in CVST mouse model and induces inflammasome activation and microglia pyroptosis

R Ding, H Li, Y Liu, W Ou, X Zhang, H Chai… - Journal of …, 2022 - Springer
Background Neuroinflammation-induced injury is intimately associated with poor prognosis
in patients with cerebral venous sinus thrombosis (CVST). The cyclic GMP-AMP synthase …

Inflammaging and brain: Curcumin and its beneficial potential as regulator of microglia activation

A Cianciulli, R Calvello, M Ruggiero, MA Panaro - Molecules, 2022 - mdpi.com
Inflammaging is a term used to describe the tight relationship between low-grade chronic
inflammation and aging that occurs during physiological aging in the absence of evident …

Regulation of N6-methyladenosine (m6A) RNA methylation in microglia-mediated inflammation and ischemic stroke

F Zhang, Y Ran, M Tahir, Z Li, J Wang… - Frontiers in cellular …, 2022 - frontiersin.org
N6-methyladenosine (m6A) is the most abundant post-transcription modification, widely
occurring in eukaryotic mRNA and non-coding RNA. m6A modification is highly enriched in …

Trends in NLRP3 inflammasome research in ischemic stroke from 2011 to 2022: a bibliometric analysis

H Zhu, Y Zhang, S Feng, Y Li, Y Ye… - CNS Neuroscience …, 2023 - Wiley Online Library
Background Ischemic stroke is a leading cause of permanent disability and death globally.
The nucleotide‐biding oligomaerization domain (NOD)‐like receptor family pyrin domain …

Engeletin alleviates cerebral ischemia reperfusion‐induced neuroinflammation via the HMGB1/TLR4/NF‐κB network

Y Xu, J Zhang, F Gao, W Cheng… - Journal of Cellular …, 2023 - Wiley Online Library
High‐mobility group box1 (HMGB1) induces inflammatory injury, and emerging reports
suggest that it is critical for brain ischemia reperfusion. Engeletin, a natural Smilax glabra …

[HTML][HTML] The role and therapeutic potential of nuclear factor κB (NF-κB) in ischemic stroke

G Xu, F Dong, L Su, ZX Tan, M Lei, L Li, D Wen… - Biomedicine & …, 2024 - Elsevier
Stroke is a prevalent cerebrovascular condition with a global impact, causing significant
rates of illness and death. Despite extensive research, the available treatment options for …

Perspectives on the mechanism of pyroptosis after intracerebral hemorrhage

D Song, CT Yeh, J Wang, F Guo - Frontiers in Immunology, 2022 - frontiersin.org
Intracerebral hemorrhage (ICH) is a highly harmful neurological disorder with high rates of
mortality, disability, and recurrence. However, effective therapies are not currently available …

DL-3-n-butylphthalide (NBP) alleviates poststroke cognitive impairment (PSCI) by suppressing neuroinflammation and oxidative stress

H Zhang, L Wang, Y Yang, C Cai, X Wang… - Frontiers in …, 2023 - frontiersin.org
Currently, the recovery of cognitive function has become an essential part of stroke
rehabilitation. DL-3-n-butylphthalide (NBP) is a neuroprotective reagent and has been used …