Cryptococcus spp., in particular Cryptococcus neoformans and Cryptococcus gattii, have an
enormous impact on human health worldwide. The global burden of cryptococcal meningitis …

CYP51 (Erg11) belongs to the cytochrome P450 monooxygenase (CYP) superfamily and
mediates a crucial step of the synthesis of ergosterol, which is a fungal-specific sterol. It is …

Fungal cells change shape in response to environmental stimuli, and these morphogenic
transitions drive pathogenesis and niche adaptation. For example, dimorphic fungi switch …

Opportunistic fungal pathogens can cause a diverse range of diseases in humans. The
increasing rate of fungal infections caused by strains that are resistant to commonly used …

Increasing resistance to frontline antifungals is a growing threat to global health. In the face
of high rates of relapse for patients with cryptococcal meningitis and frequent drug …

BACKGROUND. Cryptococcal meningitis (CM) causes an estimated 180,000 deaths
annually, predominantly in sub-Saharan Africa, where most patients receive fluconazole …

This review attempts to frame the issues around antifungal drug resistance. From its
epidemiology, mechanisms, measurements, and clinical significance, invasive fungal …

Antifungal drug tolerance is a response distinct from resistance, in which cells grow slowly
above the MIC. Here, we found that the majority (69.2%) of 133 Candida albicans clinical …

Aneuploidy, a deviation from a balanced genome by either gain or loss of chromosomes, is
generally associated with impaired fitness and developmental defects in eukaryotic …

The high morbidity and mortality of cryptococcal meningitis is due to the limited range of
therapeutic options: only three classes of antifungal drugs are available (polyenes …