Malaria is a serious parasitic disease in the developing world, causing high morbidity and
mortality. The pathogenesis of malaria is complex, and the clinical presentation of disease …

A growing body of evidence suggests that when B cells are chronically stimulated, a
phenotypically unique subset expands. Data suggest that this atypical population contains B …

Protective antibodies in Plasmodium falciparum malaria are only acquired after years of
repeated infections. Chronic malaria exposure is associated with a large increase in atypical …

Naturally acquired immunity to malaria develops slowly, requiring several years of repeated
exposure to be effective. The cellular and molecular factors underlying this observation are …

Humoral immunity is critical for viral control, but the identity and mechanisms regulating
human antiviral B cells are unclear. Here, we characterized human B cells expressing T-bet …

Antibodies can protect from Plasmodium falciparum (Pf) infection and clinical malaria
disease. However, in the absence of constant reexposure, serum immunoglobulin (Ig) levels …

Coevolution of humans and malaria parasites has generated an intricate balance between
the immune system of the host and virulence factors of the parasite, equilibrating maximal …

Malaria kills close to a million people every year, mostly children under the age of five. In the
drive towards the development of an effective vaccine and new chemotherapeutic targets for …

Exposure to Plasmodium falciparum is associated with circulating “atypical” memory B cells
(atMBCs), which appear similar to dysfunctional B cells found in HIV-infected individuals …

Several infectious and autoimmune diseases are associated with an expansion of CD21−
CD27− atypical B cells (atBCs) that up-regulate inhibitory receptors and exhibit altered B cell …