Adenosine and brain function
BB Fredholm, JF Chen, RA Cunha… - Int Rev …, 2005 - books.google.com
A. Cellular and Subcellular Localization B. Pharmacological Tools to Study Adenosine
Receptors C. Signaling Via Adenosine Receptors D. Regulation of Receptor Expression and …
Receptors C. Signaling Via Adenosine Receptors D. Regulation of Receptor Expression and …
Adenosine A2A Receptor as a Drug Discovery Target
M de Lera Ruiz, YH Lim, J Zheng - Journal of medicinal chemistry, 2014 - ACS Publications
The adenosine A2A receptor is a G-protein-coupled receptor (GPCR) that has been
extensively studied during the past few decades because it offers numerous possibilities for …
extensively studied during the past few decades because it offers numerous possibilities for …
[HTML][HTML] Adenosine receptors and brain diseases: neuroprotection and neurodegeneration
Adenosine acts in parallel as a neuromodulator and as a homeostatic modulator in the
central nervous system. Its neuromodulatory role relies on a balanced activation of inhibitory …
central nervous system. Its neuromodulatory role relies on a balanced activation of inhibitory …
[HTML][HTML] Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor
Adenosine is released from metabolically active cells by facilitated diffusion, and is
generated extracellularly by degradation of released ATP. It is a potent biological mediator …
generated extracellularly by degradation of released ATP. It is a potent biological mediator …
Adenosine–dopamine receptor–receptor interactions as an integrative mechanism in the basal ganglia
S Ferré, K Fuxe, BB Fredholm, M Morelli… - Trends in neurosciences, 1997 - cell.com
Increasing evidence suggests that antagonistic interactions between specific subtypes of
adenosine and dopamine receptors in the basal ganglia are involved in the motor …
adenosine and dopamine receptors in the basal ganglia are involved in the motor …
Opposing patterns of signaling activation in dopamine D1 and D2 receptor-expressing striatal neurons in response to cocaine and haloperidol
J Bertran-Gonzalez, C Bosch, M Maroteaux… - Journal of …, 2008 - Soc Neuroscience
Psychostimulants and other drugs of abuse activate extracellular signal-regulated kinase
(ERK) in the striatum, through combined stimulation of dopamine D 1 receptors (D1Rs) and …
(ERK) in the striatum, through combined stimulation of dopamine D 1 receptors (D1Rs) and …
Locomotion activates PKA through dopamine and adenosine in striatal neurons
The canonical model of striatal function predicts that animal locomotion is associated with
the opposing regulation of protein kinase A (PKA) in direct and indirect pathway striatal …
the opposing regulation of protein kinase A (PKA) in direct and indirect pathway striatal …
Are we dependent upon coffee and caffeine? A review on human and animal data
A Nehlig - Neuroscience & Biobehavioral Reviews, 1999 - Elsevier
Caffeine is the most widely used psychoactive substance and has been considered
occasionally as a drug of abuse. The present paper reviews available data on caffeine …
occasionally as a drug of abuse. The present paper reviews available data on caffeine …
Genetics of caffeine consumption and responses to caffeine
Rationale Caffeine is widely consumed in foods and beverages and is also used for a
variety of medical purposes. Despite its widespread use, relatively little is understood …
variety of medical purposes. Despite its widespread use, relatively little is understood …
Structure and function of adenosine receptors and their genes
BB Fredholm, G Arslan, L Halldner, B Kull… - Naunyn-Schmiedeberg's …, 2000 - Springer
Four adenosine receptors have been cloned from many mammalian and some non-
mammalian species. In each case the translated part of the receptor is encoded by two …
mammalian species. In each case the translated part of the receptor is encoded by two …