For many years, it has been suggested that drugs that interfere with dopamine (DA)
transmission alter the “rewarding” impact of primary reinforcers such as food. Research and …

Adenosine A 2a receptors are not confined to dopamine-rich areas of the brain, since
thermocycling analysis shows that adenosine A 2a receptor mRNA is expressed also in the …

This review paper is focused upon the involvement of mesolimbic dopamine (DA) and
related brain systems in effort-based processes. Interference with DA transmission affects …

Parkinson′ s disease (PD) is a progressive extrapyramidal motor disorder. Pathologically,
this disease is characterized by the selective dopaminergic (DAergic) neuronal …

Adenosine and adenosine receptors (ARs) are increasingly recognized as important
therapeutic targets for controlling cognition under normal and disease conditions for its dual …

Background: Chronic treatment with l-3, 4-dihydroxyphenylalanine (l-dopa) is often
associated with motor side effects in PD patients. The search for new therapeutic …

There is now good reason to believe that blockade of the adenosine A 2A receptor could be
of value in the treatment of Parkinson's disease. Peter J. Richardson, Hiroshi Kase and Peter …

Recent research has shown that neurons in the ventrolateral preoptic nucleus are crucial for
sleep by inhibiting wake-promoting systems, but the process that triggers their activation at …

The A2AR is largely coexpressed with D2Rs and enkephalin mRNA in the striatum where it
modulates dopaminergic activity. Activation of the A2AR antagonizes D2R-mediated …

Endogenous adenosine in nervous tissue, a central link between energy metabolism and
neuronal activity, varies according to behavioral state and (patho) physiological conditions; it …