The behavioral pharmacology of effort‐related choice behavior: dopamine, adenosine and beyond
For many years, it has been suggested that drugs that interfere with dopamine (DA)
transmission alter the “rewarding” impact of primary reinforcers such as food. Research and …
transmission alter the “rewarding” impact of primary reinforcers such as food. Research and …
Evidence for functionally important adenosine A2a receptors in the rat hippocampus
RA Cunha, B Johansson, I van der Ploeg, AM Sebastia… - Brain research, 1994 - Elsevier
Adenosine A 2a receptors are not confined to dopamine-rich areas of the brain, since
thermocycling analysis shows that adenosine A 2a receptor mRNA is expressed also in the …
thermocycling analysis shows that adenosine A 2a receptor mRNA is expressed also in the …
The pharmacology of effort-related choice behavior: Dopamine, depression, and individual differences
This review paper is focused upon the involvement of mesolimbic dopamine (DA) and
related brain systems in effort-based processes. Interference with DA transmission affects …
related brain systems in effort-based processes. Interference with DA transmission affects …
Dopamine Receptors and Parkinson′ s Disease
S Hisahara, S Shimohama - International journal of medicinal …, 2011 - Wiley Online Library
Parkinson′ s disease (PD) is a progressive extrapyramidal motor disorder. Pathologically,
this disease is characterized by the selective dopaminergic (DAergic) neuronal …
this disease is characterized by the selective dopaminergic (DAergic) neuronal …
Adenosine receptor control of cognition in normal and disease
JF Chen - International review of neurobiology, 2014 - Elsevier
Adenosine and adenosine receptors (ARs) are increasingly recognized as important
therapeutic targets for controlling cognition under normal and disease conditions for its dual …
therapeutic targets for controlling cognition under normal and disease conditions for its dual …
Antiparkinsonian effect of a new selective adenosine A2A receptor antagonist in MPTP-treated monkeys
R Grondin, PJ Bedard, AH Tahar, L Gregoire, A Mori… - Neurology, 1999 - AAN Enterprises
Background: Chronic treatment with l-3, 4-dihydroxyphenylalanine (l-dopa) is often
associated with motor side effects in PD patients. The search for new therapeutic …
associated with motor side effects in PD patients. The search for new therapeutic …
Adenosine A2A receptor antagonists as new agents for the treatment of Parkinson's disease
PJ Richardson, H Kase, PG Jenner - Trends in pharmacological sciences, 1997 - cell.com
There is now good reason to believe that blockade of the adenosine A 2A receptor could be
of value in the treatment of Parkinson's disease. Peter J. Richardson, Hiroshi Kase and Peter …
of value in the treatment of Parkinson's disease. Peter J. Richardson, Hiroshi Kase and Peter …
The endogenous somnogen adenosine excites a subset of sleep-promoting neurons via A2A receptors in the ventrolateral preoptic nucleus
Recent research has shown that neurons in the ventrolateral preoptic nucleus are crucial for
sleep by inhibiting wake-promoting systems, but the process that triggers their activation at …
sleep by inhibiting wake-promoting systems, but the process that triggers their activation at …
The role of the D2 dopamine receptor (D2R) in A2A adenosine receptor (A2AR)-mediated behavioral and cellular responses as revealed by A2A and D2 …
JF Chen, R Moratalla, F Impagnatiello… - Proceedings of the …, 2001 - National Acad Sciences
The A2AR is largely coexpressed with D2Rs and enkephalin mRNA in the striatum where it
modulates dopaminergic activity. Activation of the A2AR antagonizes D2R-mediated …
modulates dopaminergic activity. Activation of the A2AR antagonizes D2R-mediated …
Functions of neuronal adenosine receptors
Endogenous adenosine in nervous tissue, a central link between energy metabolism and
neuronal activity, varies according to behavioral state and (patho) physiological conditions; it …
neuronal activity, varies according to behavioral state and (patho) physiological conditions; it …