Nuclear pore complexes (NPCs) mediate nucleocytoplasmic exchange. They are
exceptionally large protein complexes that fuse the inner and outer nuclear membranes to …

During division, eukaryotic cells undergo a dramatic, complex and coordinated remodelling
of their cytoskeleton and membranes. For cell division to occur, chromosomes must be …

INTRODUCTION The eukaryotic nucleus protects the genome and is enclosed by the two
membranes of the nuclear envelope. Nuclear pore complexes (NPCs) perforate the nuclear …

INTRODUCTION The nucleus harbors and protects the genetic information in eukaryotes. It
is surrounded by the nuclear envelope, which separates the nucleoplasm from the cytosol …

Defects in the architecture or integrity of the nuclear envelope are associated with a variety
of human diseases. Micronuclei, one common nuclear aberration, are an origin for …

Micronuclei are small DNA-containing nuclear structures that are spatially isolated from the
main nucleus. They are frequently found in pathologies, including cancer. It was recently …

Nuclear pore complexes (NPCs) are huge protein assemblies within the nuclear envelope
(NE) that serve as selective gates for macromolecular transport between nucleus and …

Nuclear pore complexes (NPCs) are the only transport channels that cross the nuclear
envelope. Constructed from~ 500–1000 nucleoporin proteins each, they are among the …

During cell division, remodelling of the nuclear envelope enables chromosome segregation
by the mitotic spindle. The reformation of sealed nuclei requires ESCRTs (endosomal …

Nuclear pore complexes (NPCs) are channels for nucleocytoplasmic transport of proteins
and RNAs. However, it remains unclear whether composition, structure, and permeability of …